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Time course variations in the mechanisms by which cerebral oxygen delivery is maintained on exposure to hypoxia/altitude

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Imray, C. (Chris), Chan, Colin, Stubbings, Alison, Rhodes, Hannah, Patey, Susannah, Wilson, Mark H., Bailey, Damian M. and Wright, Alex D. (2014) Time course variations in the mechanisms by which cerebral oxygen delivery is maintained on exposure to hypoxia/altitude. High Altitude Medicine & Biology, Volume 15 (Number 1). pp. 21-27. doi:10.1089/ham.2013.1079

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Official URL: http://dx.doi.org/10.1089/ham.2013.1079

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Abstract

Normal cerebral function is dependent upon an adequate and continuous supply of oxygen. This study calculated cerebral blood flow based on assessment of the right middle cerebral artery (MCA) velocity (MCAVel) and MCA diameter (MCADiam) by trans-cranial Doppler and trans-cranial Duplex in normoxia, during acute exposure to 12% normobaric hypoxia for up to 6 hours, and after 3 days exposure to the equivalent altitude, 4392 m, in nine subjects. Mean (SD) MCAVel increased both after 6 hours hypoxia from 76.8 (11.4) to 97.2 (17.4) cms/sec (p<0.001), and after 3 days at altitude from 68.1 (7.5) [sea level] to 76.2 (10.2) [4392 m] (p=0.015). MCADiam increased from 5.07 (0.6) to 6.1 (0.6) mm (p<0.001) after 6 hours of 12% hypoxia. Calculated mean MCA blood flow increased after 6 hours of 12% hypoxia from 5.0 (0.6) mL/sec to 8.9 (1.2) mL/sec, but there was no difference between sea level and 4392 m. Calculated mean cerebral oxygen delivery increased from 72.4 (14.4) to 107 (20.1) mL/sec (p<0.001) after 6 hours of 12% hypoxia and was maintained unchanged at 4392 m. An increase in MCA caliber, rather than blood velocity, was a major contributor to increased oxygen delivery accompanying within the first few hours of exposure to acute hypoxia. During more long-term exposure, increases in MCA velocity and a rise in hemoglobin appeared to be the more important mechanisms in maintaining cerebral oxygen delivery. The implication of this observed change in MCA diameter questions the widely held assumption that MCA velocity is a surrogate for flow during acute hypoxic exposure.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: High Altitude Medicine & Biology
Publisher: Mary Ann Liebert, Inc. Publishers
ISSN: 1527-0297
Official Date: 27 March 2014
Dates:
DateEvent
27 March 2014Published
4 October 2013Accepted
21 July 2013Submitted
Volume: Volume 15
Number: Number 1
Page Range: pp. 21-27
DOI: 10.1089/ham.2013.1079
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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