Challis, Gregory L. (2014) Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways. Journal of Industrial Microbiology & Biotechnology, Volume 41 (Number 2). pp. 219-232. doi:10.1007/s10295-013-1383-2 ISSN 1367-5435.

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Abstract

Streptomyces, and related genera of Actinobacteria, are renowned for their ability to produce antibiotics and other bioactive natural products with a wide range of applications in medicine and agriculture. Streptomyces coelicolor A3(2) is a model organism that has been used for more than five decades to study the genetic and biochemical basis for the production of bioactive metabolites. In 2002, the complete genome sequence of S. coelicolor was published. This greatly accelerated progress in understanding the biosynthesis of metabolites known or suspected to be produced by S. coelicolor and revealed that streptomycetes have far greater potential to produce bioactive natural products than suggested by classical bioassay-guided isolation studies. In this article, efforts to exploit the S. coelicolor genome sequence for the discovery of novel natural products and biosynthetic pathways are summarized.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Journal or Publication Title:	Journal of Industrial Microbiology & Biotechnology
Publisher:	Springer
ISSN:	1367-5435
Official Date:	1 February 2014
Dates:	Date Event 1 February 2014 Published
Volume:	Volume 41
Number:	Number 2
Page Range:	pp. 219-232
DOI:	10.1007/s10295-013-1383-2
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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