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Srinivasan, Rajagopalan and Balasubramanian, Mohan K. (2014) Bacteria spring a surprise. eLife, Volume 3 . Article number e03435. doi:10.7554/eLife.03435
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Official URL: http://dx.doi.org/10.7554/eLife.03435
Abstract
Cell division involves the precise duplication of all the genetic material in the cell—both the chromosomes and the plasmid DNA—and the equal division of this material between the two daughter cells. Eukaryotes employ a structure called the mitotic spindle, which is made of microtubules, and various motor proteins to ensure proper chromosome segregation (Walczak and Heald, 2008). Bacteria, meanwhile, rely on actin-like or tubulin-like proteins to segregate plasmid DNAs (Salje et al., 2010; Oliva et al., 2012), but little is known about the segregation of chromosomes in bacteria.
In 1963, François Jacob and colleagues suggested a passive mechanism in which DNA segregation was coupled to cell elongation (Figure 1A). Although several other mechanisms have been proposed since then, the molecules that orchestrate chromosome segregation in bacteria and the details of the segregation process are only beginning to emerge.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | DNA replication, Cell division, Nucleotide sequence | ||||
| Journal or Publication Title: | eLife | ||||
| Publisher: | eLife Sciences Publications Ltd. | ||||
| ISSN: | 2050-084X | ||||
| Official Date: | 24 June 2014 | ||||
| Dates: |
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| Volume: | Volume 3 | ||||
| Article Number: | Article number e03435 | ||||
| DOI: | 10.7554/eLife.03435 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access |
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