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Screening for genes coding for putative antitumor compounds, antimicrobial and enzymatic activities from haloalkalitolerant and haloalkaliphilic bacteria strains of Algerian Sahara soils
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Selama, Okba, Amos, Gregory C. A., Djenane, Zahia, Borsetto, Chiara, Laidi, Rabah Forar, Porter, David, Nateche, Farida, Wellington, E. M. H. and Hacène, Hocine (2014) Screening for genes coding for putative antitumor compounds, antimicrobial and enzymatic activities from haloalkalitolerant and haloalkaliphilic bacteria strains of Algerian Sahara soils. BioMed Research International, 2014 . Article number 317524. doi:10.1155/2014/317524 ISSN 2314-6133.
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Official URL: http://dx.doi.org/10.1155/2014/317524
Abstract
Extreme environments may often contain unusual bacterial groups whose physiology is distinct from those of normal
environments. To satisfy the need for new bioactive pharmaceuticals compounds and enzymes, we report here the isolation of
novel bacteria from an extreme environment. Thirteen selected haloalkalitolerant and haloalkaliphilic bacteria were isolated from
Algerian Sahara Desert soils. These isolates were screened for the presence of genes coding for putative antitumor compounds using
PCR based methods. Enzymatic, antibacterial, and antifungal activities were determined by using cultural dependant methods.
Several of these isolates are typical of desert and alkaline saline soils, but, in addition, we report for the first time the presence of a
potential new member of the genus Nocardiawith particular activity against the yeast Saccharomyces cerevisiae. In addition to their
haloalkali character, the presence of genes coding for putative antitumor compounds, combined with the antimicrobial activity
against a broad range of indicator strains and their enzymatic potential, makes them suitable for biotechnology applications.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Library of Congress Subject Headings (LCSH): | Sahara, Soil microbiology -- Algeria, Bacterial genetics, Genetics, Extreme environments -- Microbiology | ||||
Journal or Publication Title: | BioMed Research International | ||||
Publisher: | Hindawi Publishing | ||||
ISSN: | 2314-6133 | ||||
Official Date: | 2014 | ||||
Dates: |
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Volume: | 2014 | ||||
Number of Pages: | 11 | ||||
Article Number: | Article number 317524 | ||||
DOI: | 10.1155/2014/317524 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | European Union (EU), Algérie.Ministère de l'Enseignement Supérieur et de la Recherche Scientifique, University of Warwick | ||||
Grant number: | 289285 (EU) |
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