Miller, Michelle A., Wright, Hayley, Ji, Chen and Cappuccio, Francesco (2014) Cross-sectional study of sleep quantity and quality and amnestic and non-amnestic cognitive function in an ageing population : the English longitudinal study of ageing (ELSA). PLoS One, Volume 9 (Numbe 6). Article number e100991. doi:10.1371/journal.pone.0100991

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Abstract

Background

The aim was to investigate the association between sleep disturbances and cognitive function in younger and older individuals from an ageing population.

Methods

3,968 male and 4,821 female white participants, aged 50 years and over, from the English Longitudinal Study of Ageing (ELSA) were studied. Information on sleep quality and quantity as well as both amnestic (memory, ACF) and non-amnestic (non-memory, nACF) function was available at Wave 4 (2008). Analysis of covariance was used to evaluate the relationship between sleep and cognitive function.

Results

After adjustment for multiple confounders in the younger group (50–64 years) duration of sleep explained 15.2% of the variance in ACF (p = 0.003) and 20.6% of nACF (p = 0.010). In the older group (65+ years) the estimates were 21.3% (p<0.001) and 25.6% (p<0.001), respectively. For sleep quality, there was a statistically significant association between sleep quality and both ACF (p<0.001) and nACF (p<0.001) in the older age group, but not in the younger age group (p = 0.586 and p = 0.373, respectively; interaction between age and sleep quality in the study sample including both age groups: p<0.001 for ACF and p = 0.018 for nACF). Sleep quality explained between 15.1% and 25.5% of the variance in cognition. The interaction with age was independent of duration of sleep. At any level of sleep duration there was a steeper association between sleep quality and ACF in the older than the younger group.

Conclusions

The associations between sleep disturbances and cognitive function vary between younger and older adults. Prospective studies will determine the temporal relationships between sleep disturbances and changes in cognition in different age groups.

Item Type:	Journal Article
Subjects:	B Philosophy. Psychology. Religion > BF Psychology H Social Sciences > HQ The family. Marriage. Woman H Social Sciences > HV Social pathology. Social and public welfare Q Science > QP Physiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Sleep, Sleep -- Physiological aspects, Sleep disorders, Sleep disorders -- Age factors -- Complications, Sleep deprivation -- Age factors, Aging, Older people, Cognition in old age, Human information processing -- Age factors
Journal or Publication Title:	PLoS One
Publisher:	Public Library of Science
ISSN:	1932-6203
Official Date:	26 June 2014
Dates:	Date Event 26 June 2014 Published 31 May 2014 Accepted 7 April 2014 Submitted
Date of first compliant deposit:	27 December 2015
Volume:	Volume 9
Number:	Numbe 6
Article Number:	Article number e100991
DOI:	10.1371/journal.pone.0100991
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	Economic and Social Research Council (Great Britain) (ESRC)
Grant number:	ES/K002910/1 (ESRC),

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