The Library
Combining enzalutamide with abiraterone, prednisone, and androgen deprivation therapy in the STAMPEDE trial
Tools
Attard, Gerhardt, Sydes, Matthew R., Mason, Malcolm D., Clarke, Noel W., Aebersold, Daniel, de Bono, Johann S., Dearnaley, David P., Parker, Chris C., Ritchie, Alastair W. S., Russell, J. Martin, Thalmann, George, Cassoly, Estelle, Millman, Robin, Matheson, David, Schiavone, Francesca, Spears, Melissa R., Parmar, Mahesh K. B. and James, Nicholas D. (2014) Combining enzalutamide with abiraterone, prednisone, and androgen deprivation therapy in the STAMPEDE trial. European Urology, 66 (5). pp. 799-802. 4. doi:10.1016/j.eururo.2014.05.038 ISSN 0302-2838.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.eururo.2014.05.038
Abstract
STAMPEDE (ClinicalTrials.gov identifier NCT00268476) is a flagship multiarm, multistage, open-label, randomised controlled trial in the United Kingdom and Switzerland evaluating the combination of novel treatment strategies with androgen deprivation therapy (ADT). This includes assessing whether effective second-line treatments should be used for patients commencing long-term ADT for the first time. The trial launched in October 2005 with five research arms compared pairwise against a common control arm (Fig. 1), and to date, >5500 men have been recruited. The celecoxib arms were closed for lack of sufficient activity at the second preplanned interim analysis [1]. The remaining original arms—zoledronic acid, docetaxel, and zoledronic acid with docetaxel—successfully recruited throughout all interim stages and closed to recruitment in March 2013. Primary outcome data from these original arms are expected in mid-2015.
Item Type: | Journal Article | ||||||
---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||
Journal or Publication Title: | European Urology | ||||||
Publisher: | Elsevier BV | ||||||
ISSN: | 0302-2838 | ||||||
Official Date: | November 2014 | ||||||
Dates: |
|
||||||
Volume: | 66 | ||||||
Number: | 5 | ||||||
Page Range: | pp. 799-802 | ||||||
Article Number: | 4 | ||||||
DOI: | 10.1016/j.eururo.2014.05.038 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |