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Silica–gelatin hybrids for tissue regeneration : inter-relationships between the process variables
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Mahony, Oliver, Yue, Sheng, Turdean-Ionescu, Claudia Adriana, Hanna, John V., Smith, Mark E., Lee, Peter D. and Jones, Julian R. (2014) Silica–gelatin hybrids for tissue regeneration : inter-relationships between the process variables. Journal of Sol-Gel Science and Technology, Volume 69 (Number 2). pp. 288-298. doi:10.1007/s10971-013-3214-3 ISSN 0928-0707.
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Official URL: http://dx.doi.org/10.1007/s10971-013-3214-3
Abstract
Owing to their diverse range of highly tailorable material properties, inorganic/organic hybrids have the potential to meet the needs of biodegradable porous scaffolds across a range of tissue engineering applications. One such hybrid platform, the silica–gelatin sol–gel system, was examined and developed in this study. These hybrid scaffolds exhibit covalently linked interpenetrating networks of organic and inorganic components, which allows for independent control over their mechanical and degradation properties. A combination of the sol–gel foaming process and freeze drying was used to create an interconnected pore network. The synthesis and processing of the scaffolds has many variables that affect their structure and properties. The focus of this study was to develop a matrix tool that shows the inter-relationship between process variables by correlating the key hybrid material properties with the synthesis parameters that govern them. This was achieved by investigating the effect of the organic (gelatin) molecular weight and collating previously reported data. Control of molecular weight of the polymer is as an avenue that allows the modification of hybrid material properties without changing the surface chemistry of the material, which is a factor that governs the cell and tissue interaction with the scaffold. This presents a significant step forward in understanding the complete potential of the silica–gelatin hybrid system as a medical device.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology R Medicine > R Medicine (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||||||
Library of Congress Subject Headings (LCSH): | Gelatin, Tissue engineering, Inorganic compounds, Organic compounds, Composite materials | ||||||||||
Journal or Publication Title: | Journal of Sol-Gel Science and Technology | ||||||||||
Publisher: | Springer New York LLC | ||||||||||
ISSN: | 0928-0707 | ||||||||||
Official Date: | 1 February 2014 | ||||||||||
Dates: |
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Volume: | Volume 69 | ||||||||||
Number: | Number 2 | ||||||||||
Page Range: | pp. 288-298 | ||||||||||
DOI: | 10.1007/s10971-013-3214-3 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Date of first compliant deposit: | 27 December 2015 | ||||||||||
Date of first compliant Open Access: | 27 December 2015 | ||||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), University of Warwick, Advantage West Midlands (AWM), European Regional Development Fund (ERDF) | ||||||||||
Grant number: | EP/E057091/1 (EPSRC), EP/E051669/1 (EPSRC), EP/I020861/1 (EPSRC), EP/I02249X/1 (EPSRC) |
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