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The association between age and the development of respiratory syncytial virus neutralising antibody responses following natural infection in infants
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Sande, Charles J., Cane, Patricia and Nokes, D. James (2014) The association between age and the development of respiratory syncytial virus neutralising antibody responses following natural infection in infants. Vaccine, Volume 32 (Number 37). pp. 4726-4729. doi:10.1016/j.vaccine.2014.05.038
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Official URL: http://dx.doi.org/10.1016/j.vaccine.2014.05.038
Abstract
To determine the age at which infants mount significant neutralising antibody responses to both natural RSV infection and live vaccines that mimic natural infection, RSV-specific neutralising antibodies in the acute and convalescent phase sera of infants with RSV infection were assayed. Age-specific incidence estimates for hospitalisation with severe RSV disease were determined and compared to age-specific neutralising antibody response patterns. Disease incidence peaked at between 2 and 3.9 months of life. Following natural infection, relative to the mean acute phase antibody titre, the mean convalescent titre was lower in the 0–1.9 month age class, no different in the 2–3.9 month age class and greater in all age classes greater than 4 months. These data suggest effective vaccination with live vaccines that mimic natural infection may not be achieved before the age of 4 months. Maternal vaccination may be an alternative to direct infant vaccination in order to protect very young babies.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||||
| Library of Congress Subject Headings (LCSH): | Respiratory syncytial virus -- Vaccination | ||||||||||
| Journal or Publication Title: | Vaccine | ||||||||||
| Publisher: | Elsevier Ltd. | ||||||||||
| ISSN: | 0264-410X | ||||||||||
| Official Date: | 20 August 2014 | ||||||||||
| Dates: |
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| Date of first compliant deposit: | 27 December 2015 | ||||||||||
| Volume: | Volume 32 | ||||||||||
| Number: | Number 37 | ||||||||||
| Page Range: | pp. 4726-4729 | ||||||||||
| DOI: | 10.1016/j.vaccine.2014.05.038 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access | ||||||||||
| Funder: | Wellcome Trust (London, England) | ||||||||||
| Grant number: | 083085 (WT), 084633 (WT) |
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