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Genomic methylation patterns in archaeological barley show de-methylation as a time-dependent diagenetic process
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Smith, Oliver , Clapham, Alan J., Rose, Pam, Liu, Yuan, Wang, Jun and Allaby, Robin G. (2014) Genomic methylation patterns in archaeological barley show de-methylation as a time-dependent diagenetic process. Scientific Reports, Volume 4 . Article number 5559. doi:10.1038/srep05559 ISSN 2045-2322.
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Official URL: http://dx.doi.org/10.1038/srep05559
Abstract
Genomic methylation is variable under biotic and abiotic stresses in plants. In particular, viral infection is thought to significantly increase genomic methylation with particularly high activity around transposable elements. Here we present the genomic methylation profiles of grains of archaeological barley (Hordeum vulgare) from several strata from a site in southern Egypt, from the Napatan to the Islamic periods (800 BCE – 1812 CE). One sample tested positive for viral infection and exhibits an unusually high degree of genomic methylation compared to the rest. A decreasing trend in global methylation levels according to deposition date showsin-situde-methylation of 5-methylcytosine, which can be described as a diagenetic process. This is most likely a deamination mediated de methylation process and is expected to lead to 5 mC . T base modifications in addition to the C . U modifications due to cytosine deamination, so represents a time-dependent process of DNA diagenesis in ancient DNA.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH426 Genetics |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Library of Congress Subject Headings (LCSH): | Genomics, Methylation | ||||||||
Journal or Publication Title: | Scientific Reports | ||||||||
Publisher: | Nature Publishing Group | ||||||||
ISSN: | 2045-2322 | ||||||||
Official Date: | 4 July 2014 | ||||||||
Dates: |
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Volume: | Volume 4 | ||||||||
Article Number: | Article number 5559 | ||||||||
DOI: | 10.1038/srep05559 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 27 December 2015 | ||||||||
Date of first compliant Open Access: | 27 December 2015 | ||||||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||||||
Grant number: | DTA BBG0177941 |
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