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The effect of triclosan coated sutures on rate of Surgical Site Infection after hip and knee replacement : a protocol for a double-blind randomised controlled trial

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Sprowson, Andrew P., Jensen, Cyrus D., Parsons, Nicholas R., Partington, Paul, Emmerson, Kevin, Carluke, Ian, Asaad, Seif, Pratt, Roland, Muller, Scott and Reed, Mike R. (2014) The effect of triclosan coated sutures on rate of Surgical Site Infection after hip and knee replacement : a protocol for a double-blind randomised controlled trial. BMC Musculoskeletal Disorders, Volume 15 (Number 1). Article number 237. doi:10.1186/1471-2474-15-237

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Official URL: http://dx.doi.org/10.1186/1471-2474-15-237

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Abstract

Background:
187,000 hip and knee joint replacements are performed every year in the National Health Service (NHS). One of the commonest complications is surgical site infection (SSI), and this represents a significant burden in terms of patient morbidity, mortality and cost to health services around the world. The aim of this randomised controlled trial (RCT) is to determine if the addition of triclosan coated sutures to a standard regimen can reduce the rate of SSI after total knee replacement (TKR) and total hip replacement (THR).
Methods:
2400 patients due to undergo a total hip or knee replacement are being recruited into this two-centre RCT. Participants are recruited before surgery and randomised to either standard care or intervention group. Participants, outcome assessors and statistician are blind to treatment allocation throughout the study. The intervention consists of triclosan coated sutures vs. standard non-coated sutures. The primary outcome is the Health protection Agency (HPA) defined superficial surgical site infection at 30 days. Secondary outcomes include HPA defined deep surgical site infection at 12 months, length of hospital stay, critical care stay, and payer costs.
Discussion:
To date there are no orthopaedic randomised controlled trials on this scale assessing the effectiveness of a surgical intervention, particularly those that can be translated across the surgical specialities. The results from this trial will inform evidence-based recommendations for suture selection in the management of patients undergoing total hip or knee replacement. If triclosan coated sutures are found to be an effective intervention, implementation into clinical practice could improve long-term outcomes for patients undergoing hip and knee replacement.

Item Type: Journal Article
Subjects: R Medicine > RD Surgery
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Artificial hip joints, Total hip replacement, Artificial knee, Total knee replacement, Infection -- Prevention
Journal or Publication Title: BMC Musculoskeletal Disorders
Publisher: Biomed Central Ltd.
ISSN: 1471-2474
Official Date: 14 July 2014
Dates:
DateEvent
14 July 2014Published
1 July 2014Accepted
4 December 2014UNSPECIFIED
Volume: Volume 15
Number: Number 1
Number of Pages: 6
Article Number: Article number 237
DOI: 10.1186/1471-2474-15-237
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Johnson & Johnson

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