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Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase
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Fullam, Elizabeth, Abuhammad, Areej, Wilson, David L., Anderton, Matthew C., Davies, Steve G., Russell, Angela J. and Sim, Edith (2011) Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase. Bioorganic & Medicinal Chemistry Letters, Volume 21 (Number 4). pp. 1185-90. doi:10.1016/j.bmcl.2010.12.099 ISSN 0960-894X.
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Official URL: http://dx.doi.org/10.1016/j.bmcl.2010.12.099
Abstract
The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Bioorganic & Medicinal Chemistry Letters | ||||
Publisher: | Pergamon-Elsevier Science Ltd. | ||||
ISSN: | 0960-894X | ||||
Official Date: | 15 February 2011 | ||||
Dates: |
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Volume: | Volume 21 | ||||
Number: | Number 4 | ||||
Page Range: | pp. 1185-90 | ||||
DOI: | 10.1016/j.bmcl.2010.12.099 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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