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Arylamine N-acetyltransferases
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Sim, Edith, Westwood, Isaac and Fullam, Elizabeth (2007) Arylamine N-acetyltransferases. Expert Opinion on Drug Metabolism & Toxicology, Volume 3 (Number 2). pp. 169-84. doi:10.1517/17425255.3.2.169 ISSN 1742-5255.
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Official URL: http://dx.doi.org/10.1517/17425255.3.2.169
Abstract
Arylamine N-acetyltransferases (NATs), known as drug- and carcinogen-metabolising enzymes, have had historic roles in cellular metabolism, carcinogenesis and pharmacogenetics, including epidemiological studies of disease susceptibility. NAT research in the past 5 years builds on that history and additionally paves the way for establishing the following new concepts in biology and opportunities in drug discovery: i) NAT polymorphisms can be used as tools in molecular anthropology to study human evolution; ii) tracing NAT protein synthesis and degradation within cells is providing insight into protein folding in cell biology; iii) studies on control of NAT gene expression may help to understand the increase in the human NAT isoenzyme, NAT1, in breast cancer; iv) a NAT homologue in mycobacteria plays an essential role in cell-wall synthesis and mycobacterial survival inside host macrophage, thus identifying a novel biochemical pathway; v) transgenic mice, with genetic modifications of all Nat genes, provide in vivo tools for drug metabolism; and vi) structures of NAT isoenzymes provide essential in silico tools for drug discovery.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Expert Opinion on Drug Metabolism & Toxicology | ||||
Publisher: | Informa Healthcare | ||||
ISSN: | 1742-5255 | ||||
Official Date: | April 2007 | ||||
Dates: |
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Volume: | Volume 3 | ||||
Number: | Number 2 | ||||
Page Range: | pp. 169-84 | ||||
DOI: | 10.1517/17425255.3.2.169 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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