Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Transient Darwinian selection in Salmonella enterica serovar Paratyphi A during 450 years of global spread of enteric fever

Tools
- Tools
+ Tools

Zhou, Zhemin, McCann, A., Weill, F. -X., Blin, C., Nair, S., Wain, J., Dougan, G. and Achtman, Mark (2014) Transient Darwinian selection in Salmonella enterica serovar Paratyphi A during 450 years of global spread of enteric fever. Proceedings of the National Academy of Sciences of the United States of America, Volume 111 (Number 33). pp. 12199-12204. doi:10.1073/pnas.1411012111

Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1073/pnas.1411012111

Request Changes to record.

Abstract

The most recent common ancestor of Paratyphi A, one of the most common causes of enteric fever, existed approximately 450 y ago, centuries before that disease was clinically recognized. Subsequent changes in the genomic sequences included multiple mutations and acquisitions or losses of genes, including bacteriophages and genomic islands. Some of those evolutionary changes were reliably attributed to Darwinian selection, but that selection was only transient, and many genetic changes were subsequently lost because they rendered the bacteria less fit (purifying selection). We interpret the history of Paratyphi A as reflecting drift rather than progressive evolution and suggest that most recent increases in frequencies of bacterial diseases are due to environmental changes rather than the novel evolution of pathogenic bacteria.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection
Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Proceedings of the National Academy of Sciences of the United States of America
Publisher: National Academy of Sciences
ISSN: 0027-8424
Official Date: 19 August 2014
Dates:
DateEvent
19 August 2014Published
14 July 2014Accepted
12 June 2014Submitted
Volume: Volume 111
Number: Number 33
Page Range: pp. 12199-12204
DOI: 10.1073/pnas.1411012111
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us