McFarlane, Ramsay J., Mian, Saira and Dalgaard, Jacob Z.. (2010) The many facets of the Tim-Tipin protein families' roles in chromosome biology. Cell Cycle, Vol.9 (No.4). pp. 700-705. ISSN 1538-4101

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Abstract

Failures in DNA replication are a potent force for driving genome instability. The proteins which form the replisome, the DNA replication machinery, play a fundamental role in preventing replicative catastrophes. The Tim (TIMELESS/TIMEOUT) and Tipin proteins are two conserved replisome associated proteins which have functions in preventing replication fork collapse and replicative checkpoint signalling in response to factors which slow the progression of the replisome. Intriguingly, TIMELESS family members have been implicated in the regulation of the biological clock, giving a tantalising pointer to a possible link between DNA replication and circadian rhythm control. Here we report on our current understanding of the many facets of these protein families in maintaining genome stability and replication checkpoint control.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Cell Biology Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Cell Cycle
Publisher:	Landes Bioscience
ISSN:	1538-4101
Date:	15 February 2010
Volume:	Vol.9
Number:	No.4
Number of Pages:	6
Page Range:	pp. 700-705
Identification Number:	10.4161/cc.9.4.10676
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/6242

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