The many facets of the Tim-Tipin protein families' roles in chromosome biology
McFarlane, Ramsay J., Mian, Saira and Dalgaard, Jacob Z.. (2010) The many facets of the Tim-Tipin protein families' roles in chromosome biology. Cell Cycle, Vol.9 (No.4). pp. 700-705. ISSN 1538-4101Full text not available from this repository.
Official URL: http://dx.doi.org/10.4161/cc.9.4.10676
Failures in DNA replication are a potent force for driving genome instability. The proteins which form the replisome, the DNA replication machinery, play a fundamental role in preventing replicative catastrophes. The Tim (TIMELESS/TIMEOUT) and Tipin proteins are two conserved replisome associated proteins which have functions in preventing replication fork collapse and replicative checkpoint signalling in response to factors which slow the progression of the replisome. Intriguingly, TIMELESS family members have been implicated in the regulation of the biological clock, giving a tantalising pointer to a possible link between DNA replication and circadian rhythm control. Here we report on our current understanding of the many facets of these protein families in maintaining genome stability and replication checkpoint control.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Divisions:||Faculty of Medicine > Warwick Medical School > Biomedical Cell Biology
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Cell Cycle|
|Official Date:||15 February 2010|
|Number of Pages:||6|
|Page Range:||pp. 700-705|
|Access rights to Published version:||Restricted or Subscription Access|
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