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Gene expression signatures from three genetically separable resistance gene signaling pathways for downy mildew resistance
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Eulgem, Thomas , Weigman, Victor J., Chang, Hur-Song , McDowell, John M., Holub, E. B., Glazebrook, Jane , Zhu, Tong and Dang, Jeffery L. (2004) Gene expression signatures from three genetically separable resistance gene signaling pathways for downy mildew resistance. Plant Physiology, Volume 135 (Number 2). pp. 1129-1144. doi:10.1104/pp.104.040444 ISSN 0032-0889.
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Official URL: http://dx.doi.org/10.1104/pp.104.040444
Abstract
Resistance gene-dependent disease resistance to pathogenic microorganisms is mediated by genetically separable regulatory
pathways. Using the GeneChip Arabidopsis genome array, we compared the expression profiles of approximately 8,000
Arabidopsis genes following activation of three RPP genes directed against the pathogenic oomycete Peronospora parasitica.
Judicious choice of P. parasitica isolates and loss of resistance plant mutants allowed us to compare the responses controlled by
three genetically distinct resistance gene-mediated signaling pathways. We found that all three pathways can converge,
leading to up-regulation of common sets of target genes. At least two temporal patterns of gene activation are triggered by two
of the pathways examined. Many genes defined by their early and transient increases in expression encode proteins that
execute defense biochemistry, while genes exhibiting a sustained or delayed expression increase predominantly encode
putative signaling proteins. Previously defined and novel sequence motifs were found to be enriched in the promoters of genes
coregulated by the local defense-signaling network. These putative promoter elements may operate downstream from signal
convergence points.
Item Type: | Journal Article | ||||||||
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Alternative Title: | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Warwick HRI (2004-2010) |
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Journal or Publication Title: | Plant Physiology | ||||||||
Publisher: | American Society of Plant Biologists | ||||||||
ISSN: | 0032-0889 | ||||||||
Official Date: | 4 June 2004 | ||||||||
Dates: |
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Volume: | Volume 135 | ||||||||
Number: | Number 2 | ||||||||
Page Range: | pp. 1129-1144 | ||||||||
DOI: | 10.1104/pp.104.040444 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published |
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