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The maintenance of extreme amino acid diversity at the disease resistance gene, RPP13, in Arabidopsis thaliana

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Rose, L. E., Bittner-Eddy , Peter D., Langley, Charles H, Michelmore, Richard W, Holub, E. B. and Beynon, Jim (2004) The maintenance of extreme amino acid diversity at the disease resistance gene, RPP13, in Arabidopsis thaliana. Genetics, Volume 166 (Number 3). pp. 1517-1527. doi:10.1534/genetics.166.3.1517

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Official URL: http://dx.doi.org/10.1534/genetics.166.3.1517

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Abstract

We have used the naturally occurring plant-parasite system of Arabidopsis thaliana and its common parasite Peronospora parasitica (downy mildew) to study the evolution of resistance specificity in the host population. DNA sequence of the resistance gene, RPP13, from 24 accessions, including 20 from the United Kingdom, revealed amino acid sequence diversity higher than that of any protein coding gene reported so far in A. thaliana. A significant excess of amino acid polymorphism segregating within this species is localized within the leucine-rich repeat (LRR) domain of RPP13. These results indicate that single alleles of the gene have not swept through the population, but instead, a diverse collection of alleles have been maintained. Transgenic complementation experiments demonstrate functional differences among alleles in their resistance to various pathogen isolates, suggesting that the extreme amino acid polymorphism in RPP13 is maintained through continual reciprocal selection between host and pathogen.

Item Type: Journal Article
Divisions: Faculty of Science > Life Sciences (2010- )
Faculty of Science > Life Sciences (2010- ) > Warwick HRI (2004-2010)
Journal or Publication Title: Genetics
Publisher: Genetics Society of America
ISSN: 0016-6731
Official Date: 1 March 2004
Dates:
DateEvent
1 March 2004Published
17 December 2003Accepted
22 May 2003Submitted
Volume: Volume 166
Number: Number 3
Page Range: pp. 1517-1527
DOI: 10.1534/genetics.166.3.1517
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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