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Effector specialization in a lineage of the irish potato famine pathogen
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Dong, S., Stam, R., Cano, L. M., Song, J., Sklenar, J., Yoshida, K., Bozkurt, T. O., Oliva, R., Liu, Z., Tian, M., Win, J., Banfield, M. J., Jones, Alexandra M., van der Hoorn, R. A. L. and Kamoun, S. (2014) Effector specialization in a lineage of the irish potato famine pathogen. Science, Volume 343 (Number 6170). pp. 552-555. doi:10.1126/science.1246300 ISSN 0036-8075.
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Official URL: http://dx.doi.org/10.1126/science.1246300
Abstract
Accelerated gene evolution is a hallmark of pathogen adaptation following a host jump. Here, we describe the biochemical basis of adaptation and specialization of a plant pathogen effector after its colonization of a new host. Orthologous protease inhibitor effectors from the Irish potato famine pathogen, Phytophthora infestans, and its sister species, Phytophthora mirabilis, which is responsible for infection of Mirabilis jalapa, are adapted to protease targets unique to their respective host plants. Amino acid polymorphisms in both the inhibitors and their target proteases underpin this biochemical specialization. Our results link effector specialization to diversification and speciation of this plant pathogen.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Science | ||||
Publisher: | American Association for the Advancement of Science | ||||
ISSN: | 0036-8075 | ||||
Official Date: | 31 January 2014 | ||||
Dates: |
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Volume: | Volume 343 | ||||
Number: | Number 6170 | ||||
Page Range: | pp. 552-555 | ||||
DOI: | 10.1126/science.1246300 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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