Christian, Mark (2014) Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine. Adipocyte, Volume 3 (Number 4). doi:10.4161/adip.29853 ISSN 2162-3945.

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Abstract

Brown adipocytes help to maintain body temperature by the expression of a unique set of genes that facilitate cellular metabolic events including uncoupling protein 1-dependent thermogenesis. The dissipation of energy in brown adipose tissue (BAT) is in stark contrast to white adipose tissue (WAT) which is the body’s primary site of energy storage. However, adipose tissue is highly dynamic and upon cold exposure profound changes occur in WAT resulting in a BAT-like phenotype due to the presence of brown-in-white (BRITE) adipocytes. In our recent report, transcription profiling was used to identify the gene expression changes that underlie the browning process as well as the intrinsic differences between BAT and WAT. Neuregulin 4 was categorized as a cold-induced BAT gene encoding an adipokine that signals between adipocytes and nerve cells and likely to have a role in increasing adipose tissue innervation in response to cold.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	Adipocyte
Publisher:	Landes Bioscience
ISSN:	2162-3945
Official Date:	17 July 2014
Dates:	Date Event 17 July 2014 Available 7 July 2014 Accepted 30 April 2014 Submitted
Volume:	Volume 3
Number:	Number 4
DOI:	10.4161/adip.29853
Status:	Peer Reviewed
Publication Status:	Published
Date of first compliant deposit:	28 July 2016
Date of first compliant Open Access:	28 July 2016
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Seventh Framework Programme (European Commission) (FP7)
Grant number:	BB/H020233/1 (BBSRC), HEALTH-F2-2011-278373 (EU FP7)

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