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Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine
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Christian, Mark (2014) Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine. Adipocyte, Volume 3 (Number 4). doi:10.4161/adip.29853
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WRAP_Christian_Commentary_Revision_Accepted_All_Changes_WRAPversion.pdf - Accepted Version - Requires a PDF viewer. Download (644Kb) | Preview |
Official URL: http://dx.doi.org/10.4161/adip.29853
Abstract
Brown adipocytes help to maintain body temperature by the expression of a unique set of genes that facilitate cellular metabolic events including uncoupling protein 1-dependent thermogenesis. The dissipation of energy in brown adipose tissue (BAT) is in stark contrast to white adipose tissue (WAT) which is the body’s primary site of energy storage. However, adipose tissue is highly dynamic and upon cold exposure profound changes occur in WAT resulting in a BAT-like phenotype due to the presence of brown-in-white (BRITE) adipocytes. In our recent report, transcription profiling was used to identify the gene expression changes that underlie the browning process as well as the intrinsic differences between BAT and WAT. Neuregulin 4 was categorized as a cold-induced BAT gene encoding an adipokine that signals between adipocytes and nerve cells and likely to have a role in increasing adipose tissue innervation in response to cold.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Adipocyte | ||||||||
| Publisher: | Landes Bioscience | ||||||||
| ISSN: | 2162-3945 | ||||||||
| Official Date: | 17 July 2014 | ||||||||
| Dates: |
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| Volume: | Volume 3 | ||||||||
| Number: | Number 4 | ||||||||
| DOI: | 10.4161/adip.29853 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Seventh Framework Programme (European Commission) (FP7) | ||||||||
| Grant number: | BB/H020233/1 (BBSRC), HEALTH-F2-2011-278373 (EU FP7) |
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