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Risk factors for UK Plasmodium falciparum cases
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Pinsent, Amy, Read, Jonathan M., Griffin, Jamie T., Smith, Valerie, Gething, Peter W., Ghani, Azra C., Pasvol, G. (Geoffrey) and Hollingsworth, T. Déirdre (2014) Risk factors for UK Plasmodium falciparum cases. Malaria Journal, Volume 13 (Number 1). Article number 298. doi:10.1186/1475-2875-13-298
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Official URL: http://dx.doi.org/10.1186/1475-2875-13-298
Abstract
Background
An increasing proportion of malaria cases diagnosed in UK residents with a history of travel to malaria endemic areas are due to Plasmodium falciparum.
Methods
In order to identify travellers at most risk of acquiring malaria a proportional hazards model was used to estimate the risk of acquiring malaria stratified by purpose of travel and age whilst adjusting for entomological inoculation rate (EIR) and duration of stay in endemic countries.
Results
Travellers visiting friends and relatives and business travellers were found to have significantly higher hazard of acquiring malaria (adjusted hazard ratio (HR) relative to that of holiday makers 7.4, 95% CI 6. 4-8. 5, p < 0. 0001 and HR 3.4, 95% CI 2.9-3.8, p < 0. 0001, respectively). All age-groups were at lower risk than children aged 0-15 years.
Conclusions
These estimates of the increased risk for these groups accounting for exposure should be used to inform programmes to improve awareness of the risks of malaria when travelling.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine | ||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Plasmodium falciparum, Malaria -- Great Britain, Malaria -- Mathematical models, Malaria -- Risk factors | ||||||||
| Journal or Publication Title: | Malaria Journal | ||||||||
| Publisher: | BioMed Central Ltd. | ||||||||
| ISSN: | 1475-2875 | ||||||||
| Official Date: | 4 August 2014 | ||||||||
| Dates: |
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| Volume: | Volume 13 | ||||||||
| Number: | Number 1 | ||||||||
| Article Number: | Article number 298 | ||||||||
| DOI: | 10.1186/1475-2875-13-298 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Imperial College, London, Bill & Melinda Gates Foundation, Medical Research Council (Great Britain) (MRC), Economic and Social Research Council (Great Britain) (ESRC), Wellcome Trust (London, England) | ||||||||
| Grant number: | ES/K004255/1 (ESRC), #K00669X (MRC), #OPP1068048 (BMGF), 097830/Z/11/A-C (WT) |
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