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Arabidopsis SGT1b is required for defense signaling conferred by several downy mildew resistance genes
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Tör, Mahmut, Gordon, Pam, Cuzick, Alayne, Eulgem, Thomas, Sinapidou, Evaggelia, Mert-Turk, Figen, Can, Canan, Dangl, J. L. (Jeffery L.) and Holub, E. B. (2002) Arabidopsis SGT1b is required for defense signaling conferred by several downy mildew resistance genes. The Plant Cell, Volume 14 (Number 5). pp. 993-1003. doi:10.1105/tpc.001123 ISSN 1040-4651.
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Official URL: http://dx.doi.org/10.1105/tpc.001123
Abstract
We describe the identification of a mutant in the Arabidopsis accession Columbia (Col-0) that exhibits enhanced downy mildew (edm1) susceptibility to several Peronospora parasitica isolates, including the RPP7-diagnostic isolate Hiks1. The mutation was mapped to chromosome IV and characterized physically as a 35-kb deletion spanning seven genes. One of these genes complemented the mutant to full wild-type resistance against all of the Peronospora isolates tested. This gene (AtSGT1b) encodes a predicted protein of 39.8 kD and is an Arabidopsis ortholog of yeast SGT1, which was described originally as a key regulatory protein in centromere function and ubiquitin-mediated proteolysis. AtSGT1b contains three tetratricopeptide repeats at the N terminus followed by a bipartite chord-containing SGT domain and an SGT-specific domain at the C terminus. We discuss the role of AtSGT1b in disease resistance and its possible involvement in ubiquitin-mediated proteolysis in plants.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Journal or Publication Title: | The Plant Cell | ||||||||
Publisher: | American Society of Plant Biologists | ||||||||
ISSN: | 1040-4651 | ||||||||
Official Date: | 2 May 2002 | ||||||||
Dates: |
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Volume: | Volume 14 | ||||||||
Number: | Number 5 | ||||||||
Page Range: | pp. 993-1003 | ||||||||
DOI: | 10.1105/tpc.001123 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) |
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