Sideratou, Zili, Foundis, John, Tsiourvas, Dimitris, Nezis, I. P., Papadimas, Georgios and Paleos, Constantinos M. (2002) A novel dendrimeric “glue” for adhesion of phosphatidyl choline-based liposomes. Langmuir, Volume 18 (Number 13). pp. 5036-5039. doi:10.1021/la020150i ISSN 0743-7463.

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Abstract

The interaction of phosphatidyl choline−cholesterol liposomes incorporating dihexadecyl phosphate as recognizable lipid with complementary guanidinylated diaminobutane poly(propylene imine) dendrimers of the fourth and fifth generation afforded liposome−dendrimer aggregates which were redispersed by the addition of an excess of a phosphate buffer. The higher generation dendrimeric derivative proved more effective when interacted with liposomes. This behavior was attributed to multivalent effects, which, as generally established, enhance the reactivity of multifunctional particles. Turbidimetry, atomic force microscopy (AFM) and optical microscopy were used for investigating the interaction of the complementary particles while the redispersion of the aggregates was studied by transmission electron microscopy (TEM). Liposomal membrane stability in the collapse and redispersion processes was assessed by the calcein fluorescence method, TEM, and AFM.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Journal or Publication Title:	Langmuir
Publisher:	American Chemical Society
ISSN:	0743-7463
Official Date:	2002
Dates:	Date Event 2002 UNSPECIFIED
Volume:	Volume 18
Number:	Number 13
Page Range:	pp. 5036-5039
DOI:	10.1021/la020150i
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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