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Modes of programmed cell death during Ceratitis capitata oogenesis
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Nezis, I. P., Modes, Vassilis, Mpakou, Vicky, Stravopodis, Dimitrios J., Papassideri, Issidora S., Mammali, Ioanna and Margaritis, Lukas H. (2003) Modes of programmed cell death during Ceratitis capitata oogenesis. Tissue and Cell , Volume 35 (Number 2). pp. 113-119. doi:10.1016/S0040-8166(03)00010-7 ISSN 0040-8166.
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Official URL: http://dx.doi.org/10.1016/S0040-8166(03)00010-7
Abstract
In the present study, we demonstrate the existence of two distinct apoptotic patterns in nurse cells during Ceratitis capitata oogenesis. One is developmentally regulated and normally occurs during stages 12 and 13, and the other is stage specific and is sporadically observed during stages 7 and 8. The pre-apoptotic manifestation of the first pattern begins at stage 11 and is characterized by the formation of actin bundles. Subsequently, at stages 12 and 13, the nurse cell nuclei exhibit condensed chromatin and contain fragmented DNA, as revealed by TUNEL assay. The apoptotic nurse cell remnants are phagocytosed by the neighboring follicle cells at the end of oogenesis during stages 13 and 14. In the second apoptotic pattern, which occurs sporadically during stages 7 and 8, the nurse cells degenerate and are phagocytosed by the follicular epithelium that contains apoptotic cell bodies. The data presented herein, compared to previous reported results in Drosophila melanogaster and Dacus oleae ( and ), strongly suggest that nurse cell apoptosis is a developmentally regulated and phylogenetically conserved mechanism in higher Dipteran. They also suggest that, the sporadic apoptotic pattern consists of a possible protective mechanism throughout oogenesis when damaged or abnormal egg chambers, are eliminated before they reach maturity.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Tissue and Cell | ||||
Publisher: | Churchill Livingstone | ||||
ISSN: | 0040-8166 | ||||
Official Date: | 2003 | ||||
Dates: |
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Volume: | Volume 35 | ||||
Number: | Number 2 | ||||
Page Range: | pp. 113-119 | ||||
DOI: | 10.1016/S0040-8166(03)00010-7 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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