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Autophagy is required for the degeneration of the ovarian follicular epithelium in higher diptera
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Nezis, I. P., Stravopodis, Dimitrios J., Margaritis, Lukas H. and Papassideri, Issidora S. (2006) Autophagy is required for the degeneration of the ovarian follicular epithelium in higher diptera. Autophagy, Volume 2 (Number 4). pp. 297-298. doi:10.4161/auto.2858 ISSN 1554-8627.
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Official URL: http://dx.doi.org/10.4161/auto.2858
Abstract
Autophagy is a major pathway for the degradation of long-lived proteins and cytoplasmic organelles and an essential part of programmed cell death, as well. Our findings indicate that programmed cell death of the ovarian follicle cells in the higher Diptera species Bactrocera oleae and Ceratitis capitata manifests features of autophagic cell death. The follicle cells during the developmental stage 14 contain autophagic vacuoles and they do not exhibit caspase activity in any area of the egg chamber. Their nuclei are characterized by condensed chromatin, accompanied with high—but not low—molecular weight DNA fragmentation events exclusively detected in distinct cells of the anterior pole. The above results are likely associated with the abundant phagocytosis observed at the entry of the lateral oviducts, where numerous cell bodies are massively engulfed by epithelial cells. The similarity of the cell death process among B. oleae, C. capitata and Drosophila melanogaster species strongly suggests that autophagy-mediated cell death is conserved in higher Diptera species.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Autophagy | ||||
Publisher: | Landes Bioscience | ||||
ISSN: | 1554-8627 | ||||
Official Date: | 2006 | ||||
Dates: |
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Volume: | Volume 2 | ||||
Number: | Number 4 | ||||
Page Range: | pp. 297-298 | ||||
DOI: | 10.4161/auto.2858 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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