Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Time flies : autophagy during ageing in Drosophila

Tools
- Tools
+ Tools

Shultz, Sebastian Wolfgang, Brech, Andreas and Nezis, I. P. (2013) Time flies : autophagy during ageing in Drosophila. In: Bailly, Yannick, (ed.) Autophagy : a double-edged sword : cell survival or death? Croatia: In-Tech. ISBN 9789535110620

[img]
Preview
PDF
WRAP_1173218-lf-050814-intech-time_flies_autophagy_during_ageing_in_drosophila.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution.

Download (1059Kb) | Preview
Official URL: http://dx.doi.org/10.5772/55396

Request Changes to record.

Abstract

The process of ageing compromises the age-associated decrease in fertility, gradual loss of function, and increased vulnerability to disease, which progressively diminishes the capability of an organism to survive [1-3]. Unsurprisingly, in the past years it has been of great interest to understand which factors influence this inevitable and complex process. As a result a wide array of molecular and cellular damages has been identified and shown to accumulate during ageing. The lifelong accumulation of such damages will eventually result in frailty and disease [4]. The variety of identified age-dependent damages has given rise to different theories for molecular ageing mechanisms. These mechanisms include decreased cellular capacity to deal with DNA damage, and decline in cellular division capacity, which is linked to the progressive shortening of telomeres upon each cell cycle. Also an increased accumulation of damaged mitochondria and the involved increase in reactive oxygen species (ROS) production and decline in ATP synthesis has been shown to occur over time (reviewed in [5]). One of the phenotypic hallmarks of aged cells is the intracellular accumulation of damaged proteins and therefore protein turnover/protein degradation has attracted attention over the last years [2].

At the same time, forward genetics have allowed to investigate single gene alterations and their influence on lifespan of whole organisms. Even though the ageing process is without doubt influenced by stochastic and environmental factors, single gene mutations were shown to extend lifespan in worms, flies, and mice, suggesting the existence of a central process of ageing [6, 7]. Many of the genetic manipulations that alter longevity affect metabolism, nutrient sensing and stress response pathways. As all these pathways are connected to autophagy (an important player also in protein turnover), the question about the role of autophagy in ageing has come more and more to the fore. In this chapter we will focus on how research conducted in the excellent genetic model system Drosophila melanogaster has contributed to understand more about the interplay of autophagy and ageing.

Item Type: Book Item
Subjects: Q Science > QL Zoology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Autophagic vacuoles, Drosophila -- Aging
Publisher: In-Tech
Place of Publication: Croatia
ISBN: 9789535110620
Book Title: Autophagy : a double-edged sword : cell survival or death?
Editor: Bailly, Yannick
Official Date: 16 April 2013
Dates:
DateEvent
16 April 2013Published
15 November 2012Submitted
DOI: 10.5772/55396
Status: Peer Reviewed
Publication Status: Published
Date of first compliant deposit: 28 July 2016
Date of first compliant Open Access: 28 July 2016

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us