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Polyacrylic acid modifies local and lateral mobilities in lipid membranes
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Munavirov, Bulat V., Filippov, Andrey V., Rudakova, Maya A. and Antzutkin, Oleg N. (2014) Polyacrylic acid modifies local and lateral mobilities in lipid membranes. Journal of Dispersion Science and Technology, Volume 35 (Number 6). pp. 848-858. doi:10.1080/01932691.2013.823096 ISSN 0193-2691.
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Official URL: http://dx.doi.org/10.1080/01932691.2013.823096
Abstract
Polyacrylic acid (PAA) is a promising polymer for engineering lipid-based drug-delivery vesicles. Its unique properties allow lowering drug dose and delivery the drug close to the site of its release. To design a successful delivery scheme, however, it is important to understand on the molecular scale how the polymer interacts with lipids under various conditions in the human body. Some aspects of the PAA-lipid interaction can be revealed using physical methods, such as differential scanning microscopy, nuclear magnetic resonance spectroscopy, NMR-diffusometry, and infrared spectroscopy. This work discusses the use of these techniques as well as the peculiarities of preparing vesicular and microscopically aligned PAA-lipid systems.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||||
Journal or Publication Title: | Journal of Dispersion Science and Technology | ||||||||
Publisher: | Taylor & Francis Inc. | ||||||||
ISSN: | 0193-2691 | ||||||||
Official Date: | 14 May 2014 | ||||||||
Dates: |
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Volume: | Volume 35 | ||||||||
Number: | Number 6 | ||||||||
Page Range: | pp. 848-858 | ||||||||
DOI: | 10.1080/01932691.2013.823096 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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