Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Texture analysis of T1- and T2-weighted MR images and use of probabilistic neural network to discriminate posterior fossa tumours in children

Tools
- Tools
+ Tools

Orphanidou-Vlachou, Eleni, Vlachos, Nikolaos, Davies, Nigel P., Arvanitis, Theodoros N., Grundy, Richard G. and Peet, Andrew C. (2014) Texture analysis of T1- and T2-weighted MR images and use of probabilistic neural network to discriminate posterior fossa tumours in children. NMR in Biomedicine, Volume 27 (Number 6). pp. 632-639. doi:10.1002/nbm.3099

Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1002/nbm.3099

Request Changes to record.

Abstract

Brain tumours are the most common solid tumours in children, representing 20% of all cancers. The most frequent posterior fossa tumours are medulloblastomas, pilocytic astrocytomas and ependymomas. Texture analysis (TA) of MR images can be used to support the diagnosis of these tumours by providing additional quantitative information. MaZda software was used to perform TA on T1- and T2-weighted images of children with pilocytic astrocytomas, medulloblastomas and ependymomas of the posterior fossa, who had MRI at Birmingham Children's Hospital prior to treatment. The region of interest was selected on three slices per patient in Image J, using thresholding and manual outlining. TA produced 279 features, which were reduced using principal component analysis (PCA). The principal components (PCs) explaining 95% of the variance were used in a linear discriminant analysis (LDA) and a probabilistic neural network (PNN) to classify the cases, using DTREG statistics software. PCA of texture features from both T1- and T2-weighted images yielded 13 PCs to explain >95% of the variance. The PNN classifier for T1-weighted images achieved 100% accuracy on training the data and 90% on leave-one-out cross-validation (LOOCV); for T2-weighted images, the accuracy was 100% on training the data and 93.3% on LOOCV. A PNN classifier with T1 and T2 PCs achieved 100% accuracy on training the data and 85.8% on LOOCV. LDA classification accuracies were noticeably poorer. The features found to hold the highest discriminating potential were all co-occurrence matrix derived, where adjacent pixels had highly correlated intensities. This study shows that TA can be performed on standard T1- and T2-weighted images of childhood posterior fossa tumours using readily available software to provide high diagnostic accuracy. Discriminatory features do not correspond to those used in the clinical interpretation of the images and therefore provide novel tumour information.

Item Type: Journal Article
Divisions: Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
Journal or Publication Title: NMR in Biomedicine
Publisher: John Wiley & Sons Ltd.
ISSN: 0952-3480
Official Date: June 2014
Dates:
DateEvent
June 2014Published
May 2014Available
3 February 2014Accepted
27 January 2013Submitted
Volume: Volume 27
Number: Number 6
Page Range: pp. 632-639
DOI: 10.1002/nbm.3099
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us