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The effect of polymer nanostructure on diffusion of small molecules using tryptophan as a FRET probe
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Moore, Beth L., Lu, Annhelen, Moatsou, Dafni and O’Reilly, Rachel K. (2015) The effect of polymer nanostructure on diffusion of small molecules using tryptophan as a FRET probe. European Polymer Journal, 62 . pp. 380-385. doi:10.1016/j.eurpolymj.2014.06.003 ISSN 0014-3057.
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Official URL: http://dx.doi.org/10.1016/j.eurpolymj.2014.06.003
Abstract
The amino acid L-tryptophan has been converted into a polymerizable monomer which has been incorporated into a range of cross-linked polymeric nanogels prepared by emulsion polymerization. By using time-lapse fluorescence spectroscopy the diffusion time of a small molecule Forster resonance energy transfer (FRET) pair, dansyl amide, into the central nanogel domain has been monitored through the decreased emission of the L-tryptophan FRET donor. In this initial study it has been found that diffusion of the small molecule into the nanogels is affected by altering the synthetic parameters (cross-linking density and co-monomer hydrophobicity). When increasing the cross-linking density of the nanogels the uptake diffusion time increased, while increasing the hydrophobicity of the co-monomer (and consequently lowering the glass-transition temperature (Tg)) caused a decrease in the diffusion time.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Journal or Publication Title: | European Polymer Journal | ||||||||
Publisher: | Pergamon | ||||||||
ISSN: | 0014-3057 | ||||||||
Official Date: | January 2015 | ||||||||
Dates: |
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Volume: | 62 | ||||||||
Page Range: | pp. 380-385 | ||||||||
DOI: | 10.1016/j.eurpolymj.2014.06.003 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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