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Protein-adhesive and protein-resistant functionalized silicon surfaces
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Dobrzanska, Dorota A., Cooper, Amy L., Dowson, Christopher G., Evans, Stephen D., Haynes, Tommy, Johnson, Benjamin R. G., Stec, Helena M., Taylor, Paul C. and Marsh, Andrew (2012) Protein-adhesive and protein-resistant functionalized silicon surfaces. Langmuir . (Submitted)
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WRAP_Marsh_Langmuir Silicon_amine_oxides_28Sept2012_Final (1).pdf - Submitted Version - Requires a PDF viewer. Download (1515Kb) | Preview |
Official URL: http://pubs.acs.org/journal/langd5
Abstract
A series of new ω-alkenyl tertiary amine N-oxides is prepared in solution and immobilized on hydrofluoric acid-etched silicon {111} wafers. These monolayers are characterized by X-ray photoelectron spectroscopy, contact angle measurements, atomic force microscopy (AFM) and tested for their resistance to non-specific protein adhesion with two model proteins, lysozyme and fibrinogen. The use of silicon substrates is found to give good quality tertiary amine N-oxidemonolayers and these new surfaces are found to be significantly better at preventing non-specific protein adhesion than their parent amines as judged by AFM imaging.
Item Type: | Submitted Journal Article | ||||
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Alternative Title: | |||||
Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Semiconductors -- Design and construction, Proteins, Silicon | ||||
Journal or Publication Title: | Langmuir | ||||
Publisher: | American Chemical Society | ||||
ISSN: | 0743-7463 | ||||
Official Date: | 2012 | ||||
Dates: |
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Number of Pages: | 27 | ||||
Institution: | University of Warwick | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Submitted | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), University of Warwick, Perry Foundation (UK), Engineering and Physical Sciences Research Council (EPSRC), Birmingham Science City, Advantage West Midlands (AWM), European Regional Development Fund (ERDF) |
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