Sun, Qi, van Dam, Rob M., Meigs, James B., Franco, Oscar H., Mantzoros, Christos S. and Hu, Frank B.. (2010) Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in US women a prospective study. Diabetes, Vol.59 (No.3). pp. 611-618. ISSN 0012-1797

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Abstract

OBJECTIVE-We prospectively examined plasma levels of leptin and soluble leptin receptor (sOB-R), as well as their interactions with other diabetes risk factors, in relation to type 2 diabetes to elucidate the complex relation between these two biomarkers and diabetes risk.

RESEARCH DESIGN AND METHODS-Of 32,826 Nurses' Health Study participants who provided blood samples (luring 1989-1990, 1,054 incident case subjects of type 2 diabetes were identified and confirmed during 1990-2004 and 1,254 matched control subjects were selected. Plasma leptin and sOB-R levels were measured among these participants.

RESULTS-Aft,er multivariate adjustment for BMI, lifestyle practices, and dietary factors, sOB-R levels were significantly associated with a lower risk of type 2 diabetes. In comparison with women in the lowest, quintile, the ORs (95% CI) of developing type 2 diabetes were 0.73 (0.55-0.96), 0.51 (0.38-0.68), 0.42 (0.31-0.57), and 0.39 (0.28-0.54; P for trend < 0.0001) for women in the second to fifth quintiles of sOB-R levels, respectively. In contrast, plasma leptin levels were not significantly associated with the risk of type 2 diabetes: The OR (95% CI) was 0.82 (0.62-1.10; P for trend = 0.46) comparing the highest with the lowest quintile of leptlin levels. sOB-R levels were consistently associated with a decreased risk of type 2 diabetes at various levels of leptin or high-molecular-weight adiponectin.

CONCLUSIONS-These data suggest a strong inverse association between plasma sOB-R levels and risk of type 2 diabetes, independent of BMI, leptin, and adiponectin levels. Diabetes 59: 611-618, 2010

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Diabetes
Publisher:	American Diabetes Association
ISSN:	0012-1797
Official Date:	March 2010
Dates:	Date Event March 2010 Published
Volume:	Vol.59
Number:	No.3
Number of Pages:	8
Page Range:	pp. 611-618
Identification Number:	10.2337/db09-1343
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	National Institutes of Health and the Intramural Research Program of the National Institute of Child Health & Human Development, Unilever Postdoctoral Fellowship, American Diabetes Association, National Institute of Diabetes and Digestive and Kidney Diseases, Tanita Corporation, Beth Israel Deaconess Medical Center
Grant number:	CA-87969, DK-58845, DK-58785, K24 DK-080140
URI:	http://wrap.warwick.ac.uk/id/eprint/6281

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