Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in US women a prospective study
Sun, Qi, van Dam, Rob M., Meigs, James B., Franco, Oscar H., Mantzoros, Christos S. and Hu, Frank B.. (2010) Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in US women a prospective study. Diabetes, Vol.59 (No.3). pp. 611-618. ISSN 0012-1797Full text not available from this repository.
Official URL: http://dx.doi.org/10.2337/db09-1343
OBJECTIVE-We prospectively examined plasma levels of leptin and soluble leptin receptor (sOB-R), as well as their interactions with other diabetes risk factors, in relation to type 2 diabetes to elucidate the complex relation between these two biomarkers and diabetes risk.
RESEARCH DESIGN AND METHODS-Of 32,826 Nurses' Health Study participants who provided blood samples (luring 1989-1990, 1,054 incident case subjects of type 2 diabetes were identified and confirmed during 1990-2004 and 1,254 matched control subjects were selected. Plasma leptin and sOB-R levels were measured among these participants.
RESULTS-Aft,er multivariate adjustment for BMI, lifestyle practices, and dietary factors, sOB-R levels were significantly associated with a lower risk of type 2 diabetes. In comparison with women in the lowest, quintile, the ORs (95% CI) of developing type 2 diabetes were 0.73 (0.55-0.96), 0.51 (0.38-0.68), 0.42 (0.31-0.57), and 0.39 (0.28-0.54; P for trend < 0.0001) for women in the second to fifth quintiles of sOB-R levels, respectively. In contrast, plasma leptin levels were not significantly associated with the risk of type 2 diabetes: The OR (95% CI) was 0.82 (0.62-1.10; P for trend = 0.46) comparing the highest with the lowest quintile of leptlin levels. sOB-R levels were consistently associated with a decreased risk of type 2 diabetes at various levels of leptin or high-molecular-weight adiponectin.
CONCLUSIONS-These data suggest a strong inverse association between plasma sOB-R levels and risk of type 2 diabetes, independent of BMI, leptin, and adiponectin levels. Diabetes 59: 611-618, 2010
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine|
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Journal or Publication Title:||Diabetes|
|Publisher:||American Diabetes Association|
|Official Date:||March 2010|
|Number of Pages:||8|
|Page Range:||pp. 611-618|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||National Institutes of Health and the Intramural Research Program of the National Institute of Child Health & Human Development, Unilever Postdoctoral Fellowship, American Diabetes Association, National Institute of Diabetes and Digestive and Kidney Diseases, Tanita Corporation, Beth Israel Deaconess Medical Center|
|Grant number:||CA-87969, DK-58845, DK-58785, K24 DK-080140|
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