Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in US women a prospective study

Tools
- Tools
+ Tools

Sun, Qi, van Dam, Rob M., Meigs, James B., Franco, Oscar H., Mantzoros, Christos S. and Hu, Frank B. (2010) Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in US women a prospective study. Diabetes, Vol.59 (No.3). pp. 611-618. doi:10.2337/db09-1343

Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.2337/db09-1343

Request Changes to record.

Abstract

OBJECTIVE-We prospectively examined plasma levels of leptin and soluble leptin receptor (sOB-R), as well as their interactions with other diabetes risk factors, in relation to type 2 diabetes to elucidate the complex relation between these two biomarkers and diabetes risk.

RESEARCH DESIGN AND METHODS-Of 32,826 Nurses' Health Study participants who provided blood samples (luring 1989-1990, 1,054 incident case subjects of type 2 diabetes were identified and confirmed during 1990-2004 and 1,254 matched control subjects were selected. Plasma leptin and sOB-R levels were measured among these participants.

RESULTS-Aft,er multivariate adjustment for BMI, lifestyle practices, and dietary factors, sOB-R levels were significantly associated with a lower risk of type 2 diabetes. In comparison with women in the lowest, quintile, the ORs (95% CI) of developing type 2 diabetes were 0.73 (0.55-0.96), 0.51 (0.38-0.68), 0.42 (0.31-0.57), and 0.39 (0.28-0.54; P for trend < 0.0001) for women in the second to fifth quintiles of sOB-R levels, respectively. In contrast, plasma leptin levels were not significantly associated with the risk of type 2 diabetes: The OR (95% CI) was 0.82 (0.62-1.10; P for trend = 0.46) comparing the highest with the lowest quintile of leptlin levels. sOB-R levels were consistently associated with a decreased risk of type 2 diabetes at various levels of leptin or high-molecular-weight adiponectin.

CONCLUSIONS-These data suggest a strong inverse association between plasma sOB-R levels and risk of type 2 diabetes, independent of BMI, leptin, and adiponectin levels. Diabetes 59: 611-618, 2010

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Diabetes
Publisher: American Diabetes Association
ISSN: 0012-1797
Official Date: March 2010
Dates:
DateEvent
March 2010Published
Volume: Vol.59
Number: No.3
Number of Pages: 8
Page Range: pp. 611-618
DOI: 10.2337/db09-1343
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: National Institutes of Health and the Intramural Research Program of the National Institute of Child Health & Human Development, Unilever Postdoctoral Fellowship, American Diabetes Association, National Institute of Diabetes and Digestive and Kidney Diseases, Tanita Corporation, Beth Israel Deaconess Medical Center
Grant number: CA-87969, DK-58845, DK-58785, K24 DK-080140

Data sourced from Thomson Reuters' Web of Knowledge

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us