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Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in US women a prospective study
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Sun, Qi, van Dam, Rob M., Meigs, James B., Franco, Oscar H., Mantzoros, Christos S. and Hu, Frank B. (2010) Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in US women a prospective study. Diabetes, Vol.59 (No.3). pp. 611-618. doi:10.2337/db09-1343
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Official URL: http://dx.doi.org/10.2337/db09-1343
Abstract
OBJECTIVE-We prospectively examined plasma levels of leptin and soluble leptin receptor (sOB-R), as well as their interactions with other diabetes risk factors, in relation to type 2 diabetes to elucidate the complex relation between these two biomarkers and diabetes risk.
RESEARCH DESIGN AND METHODS-Of 32,826 Nurses' Health Study participants who provided blood samples (luring 1989-1990, 1,054 incident case subjects of type 2 diabetes were identified and confirmed during 1990-2004 and 1,254 matched control subjects were selected. Plasma leptin and sOB-R levels were measured among these participants.
RESULTS-Aft,er multivariate adjustment for BMI, lifestyle practices, and dietary factors, sOB-R levels were significantly associated with a lower risk of type 2 diabetes. In comparison with women in the lowest, quintile, the ORs (95% CI) of developing type 2 diabetes were 0.73 (0.55-0.96), 0.51 (0.38-0.68), 0.42 (0.31-0.57), and 0.39 (0.28-0.54; P for trend < 0.0001) for women in the second to fifth quintiles of sOB-R levels, respectively. In contrast, plasma leptin levels were not significantly associated with the risk of type 2 diabetes: The OR (95% CI) was 0.82 (0.62-1.10; P for trend = 0.46) comparing the highest with the lowest quintile of leptlin levels. sOB-R levels were consistently associated with a decreased risk of type 2 diabetes at various levels of leptin or high-molecular-weight adiponectin.
CONCLUSIONS-These data suggest a strong inverse association between plasma sOB-R levels and risk of type 2 diabetes, independent of BMI, leptin, and adiponectin levels. Diabetes 59: 611-618, 2010
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Diabetes | ||||
| Publisher: | American Diabetes Association | ||||
| ISSN: | 0012-1797 | ||||
| Official Date: | March 2010 | ||||
| Dates: |
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| Volume: | Vol.59 | ||||
| Number: | No.3 | ||||
| Number of Pages: | 8 | ||||
| Page Range: | pp. 611-618 | ||||
| DOI: | 10.2337/db09-1343 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | National Institutes of Health and the Intramural Research Program of the National Institute of Child Health & Human Development, Unilever Postdoctoral Fellowship, American Diabetes Association, National Institute of Diabetes and Digestive and Kidney Diseases, Tanita Corporation, Beth Israel Deaconess Medical Center | ||||
| Grant number: | CA-87969, DK-58845, DK-58785, K24 DK-080140 |
Data sourced from Thomson Reuters' Web of Knowledge
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