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Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer's disease peptide β-amyloid
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Everett, James, Céspedes, Eva, Shelford, Leigh R., Exley, Chris, Collingwood, Joanna F., Dobson, Jon, van der Laan, Gerrit, Jenkins, Catherine A., Arenholz, Elke and Telling, Neil D. (2014) Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer's disease peptide β-amyloid. Inorganic Chemistry, 53 (6). pp. 2803-2809. doi:10.1021/ic402406g ISSN 0020-1669.
An open access version can be found in:
Official URL: http://dx.doi.org/10.1021/ic402406g
Abstract
Synopsis: Here, we demonstrate that the peptide β-amyloid, which forms the senile plaques characteristic of the Alzheimer’s disease (AD) brain, has a remarkable efficiency to chemically change the benign natural iron mineral ferrihydrite to a redox-active and potentially neurotoxic form. These findings indicate that both amyloid and iron could contribute to AD pathology, and they also suggest an origin for the reactive iron minerals magnetite and wüstite, which have been found previously in Alzheimer’s tissue.
Recent work has demonstrated increased levels of redox-active iron biominerals in Alzheimer’s disease (AD) tissue. However, the origin, nature, and role of iron in AD pathology remains unclear. Using X-ray absorption, X-ray microspectroscopy, and electron microscopy techniques, we examined interactions between the AD peptide β-amyloid (Aβ) and ferrihydrite, which is the ferric form taken when iron is stored in humans. We report that Aβ is capable of reducing ferrihydrite to a pure iron(II) mineral where antiferromagnetically ordered Fe2+ cations occupy two nonequivalent crystal symmetry sites. Examination of these iron(II) phases following air exposure revealed a material consistent with the iron(II)-rich mineral magnetite. These results demonstrate the capability of Aβ to induce the redox-active biominerals reported in AD tissue from natural iron precursors. Such interactions between Aβ and ferrihydrite shed light upon the processes of AD pathogenesis, while providing potential targets for future therapies.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||
Journal or Publication Title: | Inorganic Chemistry | ||||||
Publisher: | American Chemical Society | ||||||
ISSN: | 0020-1669 | ||||||
Official Date: | 17 March 2014 | ||||||
Dates: |
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Volume: | 53 | ||||||
Number: | 6 | ||||||
Page Range: | pp. 2803-2809 | ||||||
DOI: | 10.1021/ic402406g | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Open Access Version: |
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