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Clinical and epidemiological issues in mammographic density
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Assi, Valentina, Warwick, Jane, Cuzick, Jack and Duffy, Stephen W. (2012) Clinical and epidemiological issues in mammographic density. Nature Reviews Clinical Oncology, Volume 9 (Number 1). pp. 33-40. doi:10.1038/nrclinonc.2011.173
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Official URL: http://dx.doi.org/10.1038/nrclinonc.2011.173
Abstract
High mammographic density is associated with an increased risk of breast cancer, and of all known breast cancer risk factors has the greatest attributable fraction. Mammographic density is estimated to account for 16% of all breast cancers, but can be altered by endogenous and exogenous hormonal factors, and generally declines with age. Confounding factors such as age, parity, menopausal status and BMI make the interpretation of mammographic density particularly challenging. Furthermore, none of the established means of measuring mammographic density are entirely satisfactory because they are time consuming or subjective. It is hoped that by adding information regarding mammographic density to existing models of breast cancer risk assessment, the accuracy of individual risk assessments can be improved. Although mammographic density has clearly been shown to be a powerful factor for predicting the risk of developing breast cancer, its potential role in assessing hormonal preventive regimens and helping to tailor screening algorithms cannot be fully realized until we have more-precise, simple and reproducible density measures.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Nature Reviews Clinical Oncology | ||||
| Publisher: | Nature Publishing Group | ||||
| ISSN: | 1759-4774 | ||||
| Official Date: | January 2012 | ||||
| Dates: |
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| Volume: | Volume 9 | ||||
| Number: | Number 1 | ||||
| Page Range: | pp. 33-40 | ||||
| DOI: | 10.1038/nrclinonc.2011.173 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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