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Regulation of agonist-induced Ca2+ oscillations by intraluminal Ca2+ : an experimental and theoretical study
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Hamilton, Benjamin Francis (2013) Regulation of agonist-induced Ca2+ oscillations by intraluminal Ca2+ : an experimental and theoretical study. PhD thesis, University of Warwick.
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Official URL: http://webcat.warwick.ac.uk/record=b2734275~S1
Abstract
The ubiquity of Ca2+ signalling makes understanding its underlying processes vitally important. This thesis probes one part of that system, the regulation of agonist-induced Ca2+ oscillations, using both theoretical and experimental approaches. CHO–hOT cells transfected with human oxytocin receptors are used as the vehicle to assess the mechanisms underlying oxytocin-induced Ca2+ oscillations. The methodologies used to interrogate these oscillations are
1. varying the plasmalemmal Ca2+ entry and removal;
2. manipulating Ca2+ buffering within the endoplasmic reticulum (ER) and Ca2+ uptake into the ER lumen; and
3. constructing a mathematical model that replicates the experimentally observed phenomena.
Item Type: | Thesis (PhD) | ||||
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Subjects: | Q Science > QA Mathematics Q Science > QP Physiology |
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Library of Congress Subject Headings (LCSH): | Calcium ions, Oxytocin | ||||
Official Date: | September 2013 | ||||
Dates: |
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Institution: | University of Warwick | ||||
Theses Department: | Systems Biology Doctoral Training Centre | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Shmygol, Anatoly ; Timofeeva, Yulia | ||||
Sponsors: | Biotechnology and Biological Sciences Research Council (Great Britain) | ||||
Extent: | 174 leaves : illustrations, charts | ||||
Language: | eng |
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