Hamilton, Benjamin Francis (2013) Regulation of agonist-induced Ca2+ oscillations by intraluminal Ca2+ : an experimental and theoretical study. PhD thesis, University of Warwick.

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Abstract

The ubiquity of Ca2+ signalling makes understanding its underlying processes vitally important. This thesis probes one part of that system, the regulation of agonist-induced Ca2+ oscillations, using both theoretical and experimental approaches. CHO–hOT cells transfected with human oxytocin receptors are used as the vehicle to assess the mechanisms underlying oxytocin-induced Ca2+ oscillations. The methodologies used to interrogate these oscillations are

1. varying the plasmalemmal Ca2+ entry and removal;
2. manipulating Ca2+ buffering within the endoplasmic reticulum (ER) and Ca2+ uptake into the ER lumen; and
3. constructing a mathematical model that replicates the experimentally observed phenomena.

Item Type:	Thesis (PhD)
Subjects:	Q Science > QA Mathematics Q Science > QP Physiology
Library of Congress Subject Headings (LCSH):	Calcium ions, Oxytocin
Official Date:	September 2013
Dates:	Date Event September 2013 Submitted
Institution:	University of Warwick
Theses Department:	Systems Biology Doctoral Training Centre
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Shmygol, Anatoly ; Timofeeva, Yulia
Sponsors:	Biotechnology and Biological Sciences Research Council (Great Britain)
Extent:	174 leaves : illustrations, charts
Language:	eng

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