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Regulation of agonist-induced Ca2+ oscillations by intraluminal Ca2+ : an experimental and theoretical study

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Hamilton, Benjamin Francis (2013) Regulation of agonist-induced Ca2+ oscillations by intraluminal Ca2+ : an experimental and theoretical study. PhD thesis, University of Warwick.

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Official URL: http://webcat.warwick.ac.uk/record=b2734275~S1

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Abstract

The ubiquity of Ca2+ signalling makes understanding its underlying processes vitally important. This thesis probes one part of that system, the regulation of agonist-induced Ca2+ oscillations, using both theoretical and experimental approaches. CHO–hOT cells transfected with human oxytocin receptors are used as the vehicle to assess the mechanisms underlying oxytocin-induced Ca2+ oscillations. The methodologies used to interrogate these oscillations are

1. varying the plasmalemmal Ca2+ entry and removal;
2. manipulating Ca2+ buffering within the endoplasmic reticulum (ER) and Ca2+ uptake into the ER lumen; and
3. constructing a mathematical model that replicates the experimentally observed phenomena.

Item Type: Thesis (PhD)
Subjects: Q Science > QA Mathematics
Q Science > QP Physiology
Library of Congress Subject Headings (LCSH): Calcium ions, Oxytocin
Official Date: September 2013
Dates:
DateEvent
September 2013Submitted
Institution: University of Warwick
Theses Department: Systems Biology Doctoral Training Centre
Thesis Type: PhD
Publication Status: Unpublished
Supervisor(s)/Advisor: Shmygol, Anatoly ; Timofeeva, Yulia
Sponsors: Biotechnology and Biological Sciences Research Council (Great Britain)
Extent: 174 leaves : illustrations, charts
Language: eng

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