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Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the Virion Glycome

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Crispin, Max, Harvey, David J., Bitto, David, Halldorsson, Steinar, Bonomelli, Camille, Edgeworth, Matthew, Scrivens, James H., Huiskonen, Juha T. and Bowden, Thomas A. (2014) Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the Virion Glycome. Journal of Virology, Volume 88 (Number 17). pp. 10244-10251. doi:10.1128/JVI.01662-14 ISSN 0022-538X.

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Official URL: http://dx.doi.org/10.1128/JVI.01662-14

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Abstract

Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Q Science > QR Microbiology > QR355 Virology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Bunyaviruses, Glycoproteins
Journal or Publication Title: Journal of Virology
Publisher: American Society for Microbiology
ISSN: 0022-538X
Official Date: September 2014
Dates:
DateEvent
September 2014Published
18 June 2014Available
9 June 2014Accepted
9 June 2014Submitted
Volume: Volume 88
Number: Number 17
Page Range: pp. 10244-10251
DOI: 10.1128/JVI.01662-14
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 28 December 2015
Date of first compliant Open Access: 28 December 2015
Funder: International AIDS Vaccine Initiative, Scripps Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery (CHAVI-ID), Wellcome Trust (London, England), Suomen Akatemia [Academy of Finland], Medical Research Council (Great Britain) (MRC)
Grant number: 090532/Z/09/Z (WT), 089026/Z/09/Z (WT), 130750 (AoF), 218080 (AoF), MR/L009528/1 (MRC)

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