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Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the Virion Glycome
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Crispin, Max, Harvey, David J., Bitto, David, Halldorsson, Steinar, Bonomelli, Camille, Edgeworth, Matthew, Scrivens, James H., Huiskonen, Juha T. and Bowden, Thomas A. (2014) Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the Virion Glycome. Journal of Virology, Volume 88 (Number 17). pp. 10244-10251. doi:10.1128/JVI.01662-14
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WRAP_J. Virol.-2014-Crispin-10244-51.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution. Download (3011Kb) | Preview |
Official URL: http://dx.doi.org/10.1128/JVI.01662-14
Abstract
Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | Q Science > QP Physiology Q Science > QR Microbiology > QR355 Virology |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||||||
| Library of Congress Subject Headings (LCSH): | Bunyaviruses, Glycoproteins | ||||||||||
| Journal or Publication Title: | Journal of Virology | ||||||||||
| Publisher: | American Society for Microbiology | ||||||||||
| ISSN: | 0022-538X | ||||||||||
| Official Date: | September 2014 | ||||||||||
| Dates: |
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| Date of first compliant deposit: | 28 December 2015 | ||||||||||
| Volume: | Volume 88 | ||||||||||
| Number: | Number 17 | ||||||||||
| Page Range: | pp. 10244-10251 | ||||||||||
| DOI: | 10.1128/JVI.01662-14 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access | ||||||||||
| Funder: | International AIDS Vaccine Initiative, Scripps Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery (CHAVI-ID), Wellcome Trust (London, England), Suomen Akatemia [Academy of Finland], Medical Research Council (Great Britain) (MRC) | ||||||||||
| Grant number: | 090532/Z/09/Z (WT), 089026/Z/09/Z (WT), 130750 (AoF), 218080 (AoF), MR/L009528/1 (MRC) |
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