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Pre-pregnancy care for women with pre-gestational diabetes mellitus : a systematic review and meta-analysis

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Wahabi, Haifa A. A., Alzeidan, Rasmieh A. and Esmaeil, Samia A. (2012) Pre-pregnancy care for women with pre-gestational diabetes mellitus : a systematic review and meta-analysis. BMC Public Health, Volume 12 (Number 1). Article number 792. doi:10.1186/1471-2458-12-792

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Official URL: http://dx.doi.org/10.1186/1471-2458-12-792

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Abstract

Background

Pre-gestational diabetes mellitus is associated with increased risk for maternal and fetal adverse outcomes. This systematic review was carried out to evaluate the effectiveness and safety of pre-pregnancy care in improving the rate of congenital malformations and perinatal mortality for women with pre-gestational diabetes mellitus.

Methods

We searched the following databases, MEDLINE, EMBASE, WEB OF SCIENCE, Cochrane Library, including the CENTRAL register of controlled trials and CINAHL up to December 2011, without language restriction, for any pre-pregnancy care aiming at health promotion, glycemic control and screening and treatment of diabetes complications in women with type I or type II diabetes mellitus. Study design were trials (randomized and non-randomized), cohort and case–control studies.

Results

Of the 2452 title scanned 54 full papers were retrieved of those 21 studies were included in this review. Twelve cohort studies at low and medium risk of bias, with 3088 women, were included in the meta-analysis. Meta-analysis suggested that pre-pregnancy care is effective in reducing congenital malformation, Risk Ratio (RR) 0.25 (95% CI 0.16-0.37), number needed to treat (NNT) 19 (95% CI 14–24), and perinatal mortality RR 0.34 (95% CI 0.15-0.75), NNT = 46 (95% CI 28–115). Pre-pregnancy care lowers glycosylated hemoglobin A1c (HbA1c) in the first trimester of pregnancy by an average of 1.92% (95% CI −2.05 to −1.79). However women who received pre-pregnancy care were at increased risk of hypoglycemia during the first trimester of pregnancy RR 1.51 (95% CI 1.15-1.99).

Conclusion

Pre-pregnancy care for women with pre-gestational type 1 or type 2 diabetes mellitus is effective in improving rates of congenital malformations, perinatal mortality and in reducing maternal HbA1C in the first trimester of pregnancy. Pre-pregnancy care might cause maternal hypoglycemia in the first trimester of pregnancy.

Item Type: Journal Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Pregnancy -- Complications, Diabetes, Preconception care
Journal or Publication Title: BMC Public Health
Publisher: BioMed Central Ltd.
ISSN: 1471-2458
Official Date: 17 September 2012
Dates:
DateEvent
17 September 2012Published
14 September 2012Accepted
26 April 2012Submitted
Volume: Volume 12
Number: Number 1
Article Number: Article number 792
DOI: 10.1186/1471-2458-12-792
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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