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Ectophosphodiesterase/nucleotide phosphohydrolase (Enpp) nucleotidases: cloning, conservation and developmental restriction
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Masse, Karine, Bhamra, Surinder, Allsop, Gavin, Dale, Nicholas and Jones, Elizabeth A.. (2010) Ectophosphodiesterase/nucleotide phosphohydrolase (Enpp) nucleotidases: cloning, conservation and developmental restriction. International Journal of Developmental Biology, Vol.54 (No.1). pp. 181-193. ISSN 0214-6282
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Official URL: http://dx.doi.org/10.1387/ijdb.092879km
Abstract
Ectonucleotidase proteins occupy a central role in purine signalling regulation by sequentially hydrolysing ATP to ADP and to adenosine. The ENPP (or PDNP) gene family, which encodes ectophosphodiesterase/nucleotide phosphohydrolases, is a subfamily of these enzymes, which consists of 7 members in mammals. These proteins catalyse the generation of bioactive lipids, placing the ENPP enzymes as key regulators of major physiological signalling pathways and also important players in several pathological conditions. Here we report the cloning of all the members, except enpp5, of the enpp family in Xenopus laevis and tropicalis. Phylogenetic analyses demonstrate the high level of conservation of these proteins between amphibian and other vertebrate species. During development and in the adult frog, each gene displays a distinct specific expression pattern, suggesting potentially different functions for these proteins during amphibian embryogenesis. This is the first complete developmental analysis of gene expression of this gene family in vertebrates.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) |
| Journal or Publication Title: | International Journal of Developmental Biology |
| Publisher: | Universidad del Pais Vasco * Servicio Editorial |
| ISSN: | 0214-6282 |
| Date: | 2010 |
| Volume: | Vol.54 |
| Number: | No.1 |
| Number of Pages: | 13 |
| Page Range: | pp. 181-193 |
| Identification Number: | 10.1387/ijdb.092879km |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Wellcome Trust |
| Grant number: | 082071 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/6311 |
Data sourced from Thomson Reuters' Web of Knowledge
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