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Correcting for lead time and length bias in estimating the effect of screen detection on cancer survival

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Duffy, Stephen W., Nagtegaal, I. D., Wallis, M., Cafferty, F. H., Houssami, N., Warwick, Jane, Allgood, P. C., Kearins, O., Tappenden, N., O'Sullivan, E. and Lawrence, G. (2008) Correcting for lead time and length bias in estimating the effect of screen detection on cancer survival. American Journal of Epidemiology, Volume 168 (Number 1). pp. 98-104. doi:10.1093/aje/kwn120

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Official URL: http://dx.doi.org/10.1093/aje/kwn120

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Abstract

Determination of survival time among persons with screen-detected cancer is subject to lead time and length biases. The authors propose a simple correction for lead time, assuming an exponential distribution of the preclinical screen-detectable period. Assuming two latent categories of tumors, one of which is more prone to screen detection and correspondingly less prone to death from the cancer in question, the authors have developed a strategy of sensitivity analysis for various magnitudes of length bias. Here they demonstrate these methods using a series of 25,962 breast cancer cases (1988–2004) from the West Midlands, United Kingdom.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: American Journal of Epidemiology
Publisher: Oxford University Press
ISSN: 0002-9262
Official Date: 1 July 2008
Dates:
DateEvent
1 July 2008Published
Volume: Volume 168
Number: Number 1
Page Range: pp. 98-104
DOI: 10.1093/aje/kwn120
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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