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Correcting for lead time and length bias in estimating the effect of screen detection on cancer survival
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Duffy, Stephen W., Nagtegaal, I. D., Wallis, M., Cafferty, F. H., Houssami, N., Warwick, Jane, Allgood, P. C., Kearins, O., Tappenden, N., O'Sullivan, E. and Lawrence, G. (2008) Correcting for lead time and length bias in estimating the effect of screen detection on cancer survival. American Journal of Epidemiology, Volume 168 (Number 1). pp. 98-104. doi:10.1093/aje/kwn120
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Official URL: http://dx.doi.org/10.1093/aje/kwn120
Abstract
Determination of survival time among persons with screen-detected cancer is subject to lead time and length biases. The authors propose a simple correction for lead time, assuming an exponential distribution of the preclinical screen-detectable period. Assuming two latent categories of tumors, one of which is more prone to screen detection and correspondingly less prone to death from the cancer in question, the authors have developed a strategy of sensitivity analysis for various magnitudes of length bias. Here they demonstrate these methods using a series of 25,962 breast cancer cases (1988–2004) from the West Midlands, United Kingdom.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | American Journal of Epidemiology | ||||
| Publisher: | Oxford University Press | ||||
| ISSN: | 0002-9262 | ||||
| Official Date: | 1 July 2008 | ||||
| Dates: |
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| Volume: | Volume 168 | ||||
| Number: | Number 1 | ||||
| Page Range: | pp. 98-104 | ||||
| DOI: | 10.1093/aje/kwn120 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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