The Library
A case-control study of the impact of the East Anglian breast screening programme on breast cancer mortality
Tools
Allgood, P. C., Warwick, Jane, Warren, R. M. L., Day, N. E. and Duffy, Stephen W. (2008) A case-control study of the impact of the East Anglian breast screening programme on breast cancer mortality. British Journal of Cancer, Volume 98 (Number 1). pp. 206-209. doi:10.1038/sj.bjc.6604123 ISSN 0007-0920.
|
PDF
WRAP_Warwick_6604123a.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (234Kb) | Preview |
Official URL: http://dx.doi.org/10.1038/sj.bjc.6604123
Abstract
Although breast cancer screening has been shown to work in randomised trials, there is a need to evaluate service screening programmes to ensure that they are delivering the benefit indicated by the trials. We carried out a case–control study to investigate the effect of mammography service screening, in the NHS breast screening programme, on breast cancer mortality in the East Anglian region of the UK. Cases were deaths from breast cancer in women diagnosed between the ages of 50 and 70 years, following the instigation of the East Anglia Breast Screening Programme in 1989. The controls were women (two per case) who had not died of breast cancer, from the same area, matched by date of birth to the cases. Each control was known to be alive at the time of death of her matched case. All women were known to the breast screening programme and were invited, at least once, to be screened. There were 284 cases and 568 controls. The odds ratio (OR) for risk of death from breast cancer in women who attended at least one routine screen compared to those who did not attend was 0.35 (CI: 0.24, 0.50). Adjusting for self-selection bias gave an estimate of the breast cancer mortality reduction associated with invitation to screening of 35% (OR=0.65, 95% CI: 0.48, 0.88). The effect of actually being screened was a 48% breast cancer mortality reduction (OR=0.52, 95% CI: 0.32, 0.84). The results suggest that the National Breast Screening Programme in East Anglia is achieving a reduction in breast cancer deaths, which is at least consistent with the results from the randomised controlled trials of mammographic screening.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
Library of Congress Subject Headings (LCSH): | Breast -- Cancer -- Diagnosis, Breast -- Medical examinations, Medical screening | ||||
Journal or Publication Title: | British Journal of Cancer | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 0007-0920 | ||||
Official Date: | 4 December 2008 | ||||
Dates: |
|
||||
Volume: | Volume 98 | ||||
Number: | Number 1 | ||||
Page Range: | pp. 206-209 | ||||
DOI: | 10.1038/sj.bjc.6604123 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 28 December 2015 | ||||
Date of first compliant Open Access: | 28 December 2015 |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year