Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Visually assessed breast density, breast cancer risk and the importance of the craniocaudal view

Tools
- Tools
+ Tools

Duffy, Stephen W., Nagtegaal, Iris D., Astley, Susan M., Gillan, Maureen G. C., McGee, Magnus A., Boggis, Caroline R. M., Wilson, Mary, Beetles, U., Griffiths, Miriam A., Jain, Anil K., Johnson, Jill, Roberts, Rita, Deans, Heather, Duncan, Karen A., Iyengar, Geeta, Griffiths, Pam M., Warwick, Jane, Cuzick, Jack and Gilbert, F. J. (Fiona J.) (2008) Visually assessed breast density, breast cancer risk and the importance of the craniocaudal view. Breast Cancer Research, Volume 10 (Number 4). Article number R64. doi:10.1186/bcr2123

[img]
Preview
PDF
WRAP_Warwick_bcr2123.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 2.0..

Download (209Kb) | Preview
Official URL: http://dx.doi.org/10.1186/bcr2123

Request Changes to record.

Abstract

Introduction:
Mammographic density is known to be a strong risk factor for breast cancer. A particularly strong association with risk has been observed when density is measured using interactive threshold software. This, however, is a labour-intensive process for large-scale studies.

Methods:
Our aim was to determine the performance of visually assessed percent breast density as an indicator of breast cancer risk. We compared the effect on risk of density as measured with the mediolateral oblique view only versus that estimated as the average density from the mediolateral oblique view and the craniocaudal view. Density was assessed using a visual analogue scale in 10,048 screening mammograms, including 311 breast cancer cases diagnosed at that screening episode or within the following 6 years.

Results:
Where only the mediolateral oblique view was available, there was a modest effect of breast density on risk with an odds ratio for the 76% to 100% density relative to 0% to 25% of 1.51 (95% confidence interval 0.71 to 3.18). When two views were available, there was a considerably stronger association, with the corresponding odds ratio being 6.77 (95% confidence interval 2.75 to 16.67).

Conclusion:
This indicates that a substantial amount of information on risk from percentage breast density is contained in the second view. It also suggests that visually assessed breast density has predictive potential for breast cancer risk comparable to that of density measured using the interactive threshold software when two views are available. This observation needs to be confirmed by studies applying the different measurement methods to the same individuals.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Breast -- Cancer -- Risk factors, Breast -- Medical examinations
Journal or Publication Title: Breast Cancer Research
Publisher: BioMed Central Ltd.
ISSN: 1465-542X
Official Date: 23 July 2008
Dates:
DateEvent
23 July 2008Published
Date of first compliant deposit: 28 December 2015
Volume: Volume 10
Number: Number 4
Article Number: Article number R64
DOI: 10.1186/bcr2123
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Cancer Research UK (CRUK), KWF Kankerbestrijding [Dutch Cancer Society]

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us