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Population-based family case–control proband study on familial aggregation of metabolic syndrome : finding from Taiwanese people involved in Keelung community-based integrated screening (KCIS no. 5)
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Chiu, Yueh-Hsia, Lin, Wen-Yuan, Wang, Po-En, Chen, Yao-Der, Wang, Ting-Ting, Warwick, Jane and Chen, Tony Hsiu-Hsi (2007) Population-based family case–control proband study on familial aggregation of metabolic syndrome : finding from Taiwanese people involved in Keelung community-based integrated screening (KCIS no. 5). Diabetes Research and Clinical Practice, Volume 75 (Number 3). pp. 348-356. doi:10.1016/j.diabres.2006.07.014 ISSN 0168-8227.
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Official URL: http://dx.doi.org/10.1016/j.diabres.2006.07.014
Abstract
A population-based case–control proband study was undertaken to elucidate familial aggregation, independent environmental factors, and the interaction between them. A total of 7308 metabolic syndrome (MET-S) cases were identified from the Keelung community-based integrated screening programme between 1999 and 2002. The study has a case–control/family sampling design. A total of 1417 case probands were randomly selected from 3225 metabolic syndrome cases and the corresponding 2458 controls selected from 16,519 subjects without metabolic syndrome by matching on sex, age (±3 years) and place of residence. The generalized estimation equation model was used to estimate odds ratios and corresponding 95% confidence intervals. The risk for having metabolic syndrome among family members for cases versus control probands was 1.56-fold (1.29–1.89) after controlling for significant environmental factors. Higher risk of metabolic syndrome was found in parents than spouse. Low education against high education had 2.06-fold (1.36–3.13) risk for metabolic syndrome. Betel quid chewing was positively associated with the risk of MET-S, with 1.99-fold (1.13–3.53) risk for 1–9 pieces and 1.76-fold (0.96–3.23) risk for ≥10 pieces compared with non-chewer. Moderate and high intensity of non-occupational exercise led to 21.0% (OR = 0.79 (0.63–0.98)) and 26.0% (OR = 0.74 (0.59–0.94)) reduction in the risk for metabolic syndrome, respectively. The frequent consumption of vegetable reduced 24.0% (OR = 0.76 (0.62–0.92)) risk for MET-S. The frequent consumption of coffee was associated the increased risk for metabolic syndrome (OR = 1.32 (1.07–1.64)). The present study confirmed the risk of metabolic syndrome not only has the tendency towards familial aggregation but is affected by independent effect of environmental or individual correlates.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Diabetes Research and Clinical Practice | ||||
| Publisher: | Elsevier Ltd | ||||
| ISSN: | 0168-8227 | ||||
| Official Date: | March 2007 | ||||
| Dates: |
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| Volume: | Volume 75 | ||||
| Number: | Number 3 | ||||
| Page Range: | pp. 348-356 | ||||
| DOI: | 10.1016/j.diabres.2006.07.014 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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