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A simple model for potential use with a misclassified binary outcome in epidemiology

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Duffy, S. W., Warwick, Jane, Williams, A. R. W., Keshavarz, F., Rohan, T. E., Nili, F. and Sadeghi-Hassanabadi, A. (2004) A simple model for potential use with a misclassified binary outcome in epidemiology. Journal of Epidemiology & Community Health, Volume 58 (Number 8). pp. 712-717. doi:10.1136/jech.2003.010546

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Official URL: http://dx.doi.org/10.1136/jech.2003.010546

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Abstract

Study objective: Error in determination of disease outcome occurs in epidemiology, but such error is not usually corrected for in statistical analysis. A method of correction of risk estimates for misclassification of a binary disease outcome is developed here.

Methods: The method is a simple, closed form correction to the logistic regression estimate. A closed form variance estimate is also developed.

Setting: The method is illustrated in two studies, a cross sectional survey of cervicitis in Iran in 1996–97, as determined by inflammation on cervical smear specimens, and a case-cohort study of benign proliferative epithelial disease of the breast, in Canada 1980–88.

Main results: The method provides corrected odds ratio estimates and corrects the spurious precision conferred by misclassification.

Conclusions: The method is easy to apply and potentially useful, although potential failures of the assumptions involved should be borne in mind. It is necessary to give careful consideration to the plausibility or otherwise of the assumptions in the context of the individual study. Correction for misclassification of disease outcome may become more common with the development of readily applicable methods.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Journal of Epidemiology & Community Health
Publisher: BMJ Group
ISSN: 0143-005X
Official Date: August 2004
Dates:
DateEvent
August 2004Published
Volume: Volume 58
Number: Number 8
Page Range: pp. 712-717
DOI: 10.1136/jech.2003.010546
Status: Peer Reviewed
Publication Status: Published

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