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Overdiagnosis in screening : is the increase in breast cancer incidence rates a cause for concern?

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Paci, E., Warwick, Jane, Falini, P. and Duffy, S. W. (2004) Overdiagnosis in screening : is the increase in breast cancer incidence rates a cause for concern? Journal of Medical Screening, Volume 11 (Number 1). pp. 23-27. doi:10.1258/096914104772950718

Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1258/096914104772950718

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Abstract

Objectives:
To estimate the degree of overdiagnosis of breast cancer in a mammographic screening programme.
Setting:
A mammography service screening programme in Florence, Italy.
Methods:
We studied the incidence of breast cancer in Florence between 1990 and 1999, following the introduction of screening in 1990. Incidence of breast cancer in this period was compared with incidence between 1985 and 1989, before the introduction of screening. It was necessary to estimate the number of cancers that would have arisen in the absence of screening, but after the end of followup (31 December 1999), so that these were not misclassified as overdiagnosed tumours. Around 60,000 women aged 50-69 were invited for screening during the period of study.
Results:
There were 2780 breast cancers diagnosed during the period of study (2626 were invasive). There was no significant evidence of overdiagnosis of invasive cancers. When invasive and in situ cancers were considered together, around 5% of cases were overdiagnosed.
Conclusions:
There is a small amount of overdiagnosis of ductal carcinoma in situ in mammography screening; however, this should not deter women from being screened. Training and practice in mammographic screening should emphasise detection of small, invasive lesions. Research into the natural history and treatment of the disease should aim at minimising overtreatment of those in situ lesions that are less likely to progress to invasive disease.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Journal of Medical Screening
Publisher: Sage Publications Ltd.
ISSN: 0969-1413
Official Date: 2004
Dates:
DateEvent
2004Published
Volume: Volume 11
Number: Number 1
Page Range: pp. 23-27
DOI: 10.1258/096914104772950718
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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