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Breast density and breast cancer risk factors in a high-risk population
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Warwick, Jane, Pinney, E., Warren, R. M. L, Duffy, S. W., Howell, A., Wilson, M. and Cuzick, J. (2003) Breast density and breast cancer risk factors in a high-risk population. The Breast, Volume 12 (Number 1). pp. 10-16. doi:10.1016/S0960-9776(02)00212-6 ISSN 0960-9776.
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Official URL: http://dx.doi.org/10.1016/S0960-9776(02)00212-6
Abstract
This study investigates relationships between familial and hormonal risk factors and breast density in women at high risk of developing breast cancer. The subjects are a subset of 102 women from the international breast cancer intervention study (IBIS), for whom a series of repeated measurements of breast density were available. Details of familial and hormonal risk factors for breast cancer were collected at entry and multivariate ordered logistic regression used to identify risk factors for increased breast density. Lower body mass index and nulliparity were associated with high breast density, whereas smoking was associated with lower breast density. It is not yet known whether a reduction in breast density will lead to a corresponding reduction in breast cancer risk, so we propose that changes in breast density be investigated as a potential early indicator of efficacy in chemoprevention trials for breast cancer.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | The Breast | ||||
Publisher: | Churchill Livingstone | ||||
ISSN: | 0960-9776 | ||||
Official Date: | February 2003 | ||||
Dates: |
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Volume: | Volume 12 | ||||
Number: | Number 1 | ||||
Page Range: | pp. 10-16 | ||||
DOI: | 10.1016/S0960-9776(02)00212-6 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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