Warwick, Jane, Pinney, E., Warren, R. M. L, Duffy, S. W., Howell, A., Wilson, M. and Cuzick, J. (2003) Breast density and breast cancer risk factors in a high-risk population. The Breast, Volume 12 (Number 1). pp. 10-16. doi:10.1016/S0960-9776(02)00212-6

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Abstract

This study investigates relationships between familial and hormonal risk factors and breast density in women at high risk of developing breast cancer. The subjects are a subset of 102 women from the international breast cancer intervention study (IBIS), for whom a series of repeated measurements of breast density were available. Details of familial and hormonal risk factors for breast cancer were collected at entry and multivariate ordered logistic regression used to identify risk factors for increased breast density. Lower body mass index and nulliparity were associated with high breast density, whereas smoking was associated with lower breast density. It is not yet known whether a reduction in breast density will lead to a corresponding reduction in breast cancer risk, so we propose that changes in breast density be investigated as a potential early indicator of efficacy in chemoprevention trials for breast cancer.

Item Type:	Journal Article
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	The Breast
Publisher:	Churchill Livingstone
ISSN:	0960-9776
Official Date:	February 2003
Dates:	Date Event February 2003 Published
Volume:	Volume 12
Number:	Number 1
Page Range:	pp. 10-16
DOI:	10.1016/S0960-9776(02)00212-6
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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