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Interleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsis

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Patel, R. T., Deen, K. I., Youngs, D., Warwick, Jane and Keighley, M. R. B. (1994) Interleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsis. British Journal of Surgery, Volume 81 (Number 9). pp. 1306-1308. doi:10.1002/bjs.1800810914

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Official URL: http://dx.doi.org/10.1002/bjs.1800810914

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Abstract

Levels of plasma cytokines and circulating endotoxin were assessed in 41 patients with severe intra-abdominal sepsis. Comparison was made with the Acute Physiology And Chronic Health Evaluation (APACHE) II scoring system. Blood samples were taken within 24 h of onset of the sepsis syndrome and at serial times thereafter. Increased levels of interleukin (IL) 6 (range 50–25 500 pg/ml) were detectable in all patients with sepsis. Eighteen of the 19 deaths were attributable to sepsis and higher levels of IL-6 at the onset of the sepsis syndrome correlated with a poor outcome. The sensitivity of IL-6 concentration in predicting mortality was 86·4 per cent with a specificity of 78·9 per cent and an overall correct classification rate of 82·9 per cent. IL-6 level was a better predictor than APACHE II score (sensitivity 72·7 per cent, specificity 57·9 per cent, correct classification rate 65·9 per cent). Levels of tumour necrosis factor α, IL-1β and endotoxin did not correlate with mortality rate. Plasma IL-6 concentrations may help in planning future strategies to decrease the mortality rate associated with sepsis.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: British Journal of Surgery
Publisher: John Wiley & Sons Ltd.
ISSN: 0007-1323
Official Date: September 1994
Dates:
DateEvent
September 1994Published
Volume: Volume 81
Number: Number 9
Page Range: pp. 1306-1308
DOI: 10.1002/bjs.1800810914
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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