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Interleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsis
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Patel, R. T., Deen, K. I., Youngs, D., Warwick, Jane and Keighley, M. R. B. (1994) Interleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsis. British Journal of Surgery, Volume 81 (Number 9). pp. 1306-1308. doi:10.1002/bjs.1800810914
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Official URL: http://dx.doi.org/10.1002/bjs.1800810914
Abstract
Levels of plasma cytokines and circulating endotoxin were assessed in 41 patients with severe intra-abdominal sepsis. Comparison was made with the Acute Physiology And Chronic Health Evaluation (APACHE) II scoring system. Blood samples were taken within 24 h of onset of the sepsis syndrome and at serial times thereafter. Increased levels of interleukin (IL) 6 (range 50–25 500 pg/ml) were detectable in all patients with sepsis. Eighteen of the 19 deaths were attributable to sepsis and higher levels of IL-6 at the onset of the sepsis syndrome correlated with a poor outcome. The sensitivity of IL-6 concentration in predicting mortality was 86·4 per cent with a specificity of 78·9 per cent and an overall correct classification rate of 82·9 per cent. IL-6 level was a better predictor than APACHE II score (sensitivity 72·7 per cent, specificity 57·9 per cent, correct classification rate 65·9 per cent). Levels of tumour necrosis factor α, IL-1β and endotoxin did not correlate with mortality rate. Plasma IL-6 concentrations may help in planning future strategies to decrease the mortality rate associated with sepsis.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | British Journal of Surgery | ||||
| Publisher: | John Wiley & Sons Ltd. | ||||
| ISSN: | 0007-1323 | ||||
| Official Date: | September 1994 | ||||
| Dates: |
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| Volume: | Volume 81 | ||||
| Number: | Number 9 | ||||
| Page Range: | pp. 1306-1308 | ||||
| DOI: | 10.1002/bjs.1800810914 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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