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Intervention debulking surgery in advanced epithelial ovarian cancer

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Redman, C. W. E., Warwick, Jane, Luesley, D. M., Varma, R., Lawton, F. G. and Blackledge, G. R. P. (1994) Intervention debulking surgery in advanced epithelial ovarian cancer. BJOG: An International Journal of Obstetrics and Gynaecology, Volume 101 (Number 2). pp. 142-146. doi:10.1111/j.1471-0528.1994.tb13080.x

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Official URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb13080...

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Abstract

Objective: To study whether intervention debulking surgery improves survival in patients with advanced ovarian cancer who have bulky (> 2 cm) residual disease after primary surgery.

Design: A prospective multicentre randomised study.

Setting: Hospitals in the West Midlands.

Subjects: Ovarian cancer patients with bulky residual disease after primary surgery who are considered well enough to receive cis-platinum based chemotherapy and further surgery.

Methods: Eligible patients were randomised to receive combination chemotherapy alone or combined with intervention debulking surgery.

Main: outcome measure Survival was assessed using product limit method and log-rank test.

Results: Seventy-nine patients were entered into the study. Thirty-seven patients were randomised to intervention debulking surgery, 25 (67%) of whom underwent intervention debulking surgery, which was performed a median of 13 weeks after primary surgery. The median survival for the intervention debulking surgery group was 15 months (95% CI 10–20 mo) and that of those randomised to chemotherapy alone, which was 12 months (95% CI 8–16 mo), were not significantly different (hazard ratio = 0.71; 95% CI 0.44–1.13).

Conclusion: Intervention debulking surgery may not improve survival in patients with advanced ovarian cancer.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: BJOG: An International Journal of Obstetrics and Gynaecology
Publisher: Blackwell Publishing
ISSN: 1470-0328
Official Date: February 1994
Dates:
DateEvent
February 1994Published
Volume: Volume 101
Number: Number 2
Page Range: pp. 142-146
DOI: 10.1111/j.1471-0528.1994.tb13080.x
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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