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Intervention debulking surgery in advanced epithelial ovarian cancer
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Redman, C. W. E., Warwick, Jane, Luesley, D. M., Varma, R., Lawton, F. G. and Blackledge, G. R. P. (1994) Intervention debulking surgery in advanced epithelial ovarian cancer. BJOG: An International Journal of Obstetrics and Gynaecology, Volume 101 (Number 2). pp. 142-146. doi:10.1111/j.1471-0528.1994.tb13080.x
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Official URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb13080...
Abstract
Objective: To study whether intervention debulking surgery improves survival in patients with advanced ovarian cancer who have bulky (> 2 cm) residual disease after primary surgery.
Design: A prospective multicentre randomised study.
Setting: Hospitals in the West Midlands.
Subjects: Ovarian cancer patients with bulky residual disease after primary surgery who are considered well enough to receive cis-platinum based chemotherapy and further surgery.
Methods: Eligible patients were randomised to receive combination chemotherapy alone or combined with intervention debulking surgery.
Main: outcome measure Survival was assessed using product limit method and log-rank test.
Results: Seventy-nine patients were entered into the study. Thirty-seven patients were randomised to intervention debulking surgery, 25 (67%) of whom underwent intervention debulking surgery, which was performed a median of 13 weeks after primary surgery. The median survival for the intervention debulking surgery group was 15 months (95% CI 10–20 mo) and that of those randomised to chemotherapy alone, which was 12 months (95% CI 8–16 mo), were not significantly different (hazard ratio = 0.71; 95% CI 0.44–1.13).
Conclusion: Intervention debulking surgery may not improve survival in patients with advanced ovarian cancer.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | BJOG: An International Journal of Obstetrics and Gynaecology | ||||
| Publisher: | Blackwell Publishing | ||||
| ISSN: | 1470-0328 | ||||
| Official Date: | February 1994 | ||||
| Dates: |
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| Volume: | Volume 101 | ||||
| Number: | Number 2 | ||||
| Page Range: | pp. 142-146 | ||||
| DOI: | 10.1111/j.1471-0528.1994.tb13080.x | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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