The Library
Intervention debulking surgery in advanced epithelial ovarian cancer
Tools
Redman, C. W. E., Warwick, Jane, Luesley, D. M., Varma, R., Lawton, F. G. and Blackledge, G. R. P. (1994) Intervention debulking surgery in advanced epithelial ovarian cancer. BJOG: An International Journal of Obstetrics and Gynaecology, Volume 101 (Number 2). pp. 142-146. doi:10.1111/j.1471-0528.1994.tb13080.x ISSN 1470-0328.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb13080...
Abstract
Objective: To study whether intervention debulking surgery improves survival in patients with advanced ovarian cancer who have bulky (> 2 cm) residual disease after primary surgery.
Design: A prospective multicentre randomised study.
Setting: Hospitals in the West Midlands.
Subjects: Ovarian cancer patients with bulky residual disease after primary surgery who are considered well enough to receive cis-platinum based chemotherapy and further surgery.
Methods: Eligible patients were randomised to receive combination chemotherapy alone or combined with intervention debulking surgery.
Main: outcome measure Survival was assessed using product limit method and log-rank test.
Results: Seventy-nine patients were entered into the study. Thirty-seven patients were randomised to intervention debulking surgery, 25 (67%) of whom underwent intervention debulking surgery, which was performed a median of 13 weeks after primary surgery. The median survival for the intervention debulking surgery group was 15 months (95% CI 10–20 mo) and that of those randomised to chemotherapy alone, which was 12 months (95% CI 8–16 mo), were not significantly different (hazard ratio = 0.71; 95% CI 0.44–1.13).
Conclusion: Intervention debulking surgery may not improve survival in patients with advanced ovarian cancer.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
Journal or Publication Title: | BJOG: An International Journal of Obstetrics and Gynaecology | ||||
Publisher: | Blackwell Publishing | ||||
ISSN: | 1470-0328 | ||||
Official Date: | February 1994 | ||||
Dates: |
|
||||
Volume: | Volume 101 | ||||
Number: | Number 2 | ||||
Page Range: | pp. 142-146 | ||||
DOI: | 10.1111/j.1471-0528.1994.tb13080.x | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |