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Parathyroid hormone related protein and skeletal morbidity in breast cancer
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Bundred, N. J., Morrison, J. M., Ratcliffe, W. A., Ratcliffe, J. G., Warwick, Jane and Walker, R. A. (1992) Parathyroid hormone related protein and skeletal morbidity in breast cancer. European Journal of Cancer Care, Volume 28 (Number 2-3). pp. 690-692. doi:10.1016/S0959-8049(05)80127-3
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Official URL: http://dx.doi.org/10.1016/S0959-8049(05)80127-3
Abstract
The presence of parathyroid hormone related protein (PTHRP) in human breast cancers has been assessed by immunohistochemistry using a polyclonal antiserum specific for the mid-region sequence 37–67 in an immunoperoxidase technique. The primary tumours from 155 normocalcaemic, consecutive women with early breast cancer who had been followed up for a minimum of 5 years were assessed. Dewaxed paraffin sections of formalin fixed tissue was used throughout. Positive PTHRP staining was detected in 56% of the cancers and was unrelated to standard prognostic factors, recurrence or survival. However, PTHRP positivity was related to the development of bone metastases (P ≤ 0.03) and hypercalcaemic episodes. PTHRP is implicated as the humoral factor responsible for hypercalcaemia associated with breast cancer and tumour positivity may be a useful predictor of which women will develop bone metastases.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | European Journal of Cancer Care | ||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||
| ISSN: | 0961-5423 | ||||
| Official Date: | February 1992 | ||||
| Dates: |
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| Volume: | Volume 28 | ||||
| Number: | Number 2-3 | ||||
| Page Range: | pp. 690-692 | ||||
| DOI: | 10.1016/S0959-8049(05)80127-3 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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