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Parathyroid hormone related protein and skeletal morbidity in breast cancer

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Bundred, N. J., Morrison, J. M., Ratcliffe, W. A., Ratcliffe, J. G., Warwick, Jane and Walker, R. A. (1992) Parathyroid hormone related protein and skeletal morbidity in breast cancer. European Journal of Cancer Care, Volume 28 (Number 2-3). pp. 690-692. doi:10.1016/S0959-8049(05)80127-3

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Official URL: http://dx.doi.org/10.1016/S0959-8049(05)80127-3

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Abstract

The presence of parathyroid hormone related protein (PTHRP) in human breast cancers has been assessed by immunohistochemistry using a polyclonal antiserum specific for the mid-region sequence 37–67 in an immunoperoxidase technique. The primary tumours from 155 normocalcaemic, consecutive women with early breast cancer who had been followed up for a minimum of 5 years were assessed. Dewaxed paraffin sections of formalin fixed tissue was used throughout. Positive PTHRP staining was detected in 56% of the cancers and was unrelated to standard prognostic factors, recurrence or survival. However, PTHRP positivity was related to the development of bone metastases (P ≤ 0.03) and hypercalcaemic episodes. PTHRP is implicated as the humoral factor responsible for hypercalcaemia associated with breast cancer and tumour positivity may be a useful predictor of which women will develop bone metastases.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: European Journal of Cancer Care
Publisher: Wiley-Blackwell Publishing Ltd.
ISSN: 0961-5423
Official Date: February 1992
Dates:
DateEvent
February 1992Published
Volume: Volume 28
Number: Number 2-3
Page Range: pp. 690-692
DOI: 10.1016/S0959-8049(05)80127-3
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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