Wilson, Mark H., Wright, Alex and Imray, C. (Chris) (2014) Intracranial pressure at altitude. High Altitude Medicine & Biology, Volume 15 (Number 2). pp. 123-132. doi:10.1089/ham.2013.1151

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Abstract

Rapid ascent to high altitude can result in high altitude headache, acute mountain sickness, and less commonly, high altitude cerebral or pulmonary edema. The exact mechanisms by which these clinical syndromes develop remain to be fully elucidated. Direct and indirect measures of intracranial pressure (ICP) usually demonstrate a rise in pressure when human subjects and animals are exposed to acute hypoxia. However, the correlation of ICP changes to symptoms and altitude-related illnesses has been difficult to establish. Headache, for example, may occur with vessel distension prior to a rise in ICP. This article reviews the literature both supporting and refuting an increase in ICP as the underlying mechanism of headaches and other related neurological sequelae experienced at high altitude.

Item Type:	Journal Article
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	High Altitude Medicine & Biology
Publisher:	Mary Ann Liebert, Inc. Publishers
ISSN:	1527-0297
Official Date:	27 June 2014
Dates:	Date Event 27 June 2014 Published 13 March 2014 Accepted 29 December 2013 Submitted
Volume:	Volume 15
Number:	Number 2
Page Range:	pp. 123-132
DOI:	10.1089/ham.2013.1151
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access

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