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Seven challenges in modelling pathogen dynamics within-host and across scales
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Gog, Julia R., Pellis, Lorenzo, Wood, James L. N., McLean, Angela R., Arinaminpathy, Nimalan and Lloyd-Smith, James O. (2015) Seven challenges in modelling pathogen dynamics within-host and across scales. Epidemics, Volume 10 . pp. 45-48. doi:10.1016/j.epidem.2014.09.009 ISSN 1755-4365.
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Official URL: http://dx.doi.org/10.1016/j.epidem.2014.09.009
Abstract
The population dynamics of infectious disease is a mature field in terms of theory and to some extent, application. However for microparasites, the theory and application of models of the dynamics within a single infected host is still an open field. Further, connecting across the scales – from cellular to host level, to population level – has potential to vastly improve our understanding of pathogen dynamics and evolution. Here, we highlight seven challenges in the following areas: transmission bottlenecks, heterogeneity within host, dynamic fitness landscapes within hosts, making use of next-generation sequencing data, capturing superinfection and when and how to model more than two scales.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics | ||||||||||
Library of Congress Subject Headings (LCSH): | Pathogenic microorganisms, Parasitic diseases | ||||||||||
Journal or Publication Title: | Epidemics | ||||||||||
Publisher: | Elsevier BV | ||||||||||
ISSN: | 1755-4365 | ||||||||||
Official Date: | March 2015 | ||||||||||
Dates: |
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Volume: | Volume 10 | ||||||||||
Number of Pages: | 4 | ||||||||||
Page Range: | pp. 45-48 | ||||||||||
DOI: | 10.1016/j.epidem.2014.09.009 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 28 December 2015 | ||||||||||
Date of first compliant Open Access: | 28 December 2015 | ||||||||||
Funder: | United States. Department of Homeland Security. Science and Technology Directorate, Fogarty International Center, National Institutes of Health (U.S.) (NIH), Alborada Trust, Engineering and Physical Sciences Research Council (EPSRC), National Science Foundation (U.S.) (NSF) | ||||||||||
Grant number: | EF-0928690 (NSF) |
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