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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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(2014) Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nature Communications, Volume 5 . p. 4831. doi:10.1038/ncomms5831 ISSN 2041-1723.
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Official URL: http://dx.doi.org/10.1038/ncomms5831
Abstract
Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers of European descent from up to four studies of the EArly Genetics and Lifecourse Epidemiology consortium, analysing an early (15–18 months, ‘one-word stage’, NTotal=8,889) and a later (24–30 months, ‘two-word stage’, NTotal=10,819) phase of language acquisition. For the early phase, one single-nucleotide polymorphism (rs7642482) at 3p12.3 near ROBO2, encoding a conserved axon-binding receptor, reaches the genome-wide significance level (P=1.3 × 10−8) in the combined sample. This association links language-related common genetic variation in the general population to a potential autism susceptibility locus and a linkage region for dyslexia, speech-sound disorder and reading. The contribution of common genetic influences is, although modest, supported by genome-wide complex trait analysis (meta-GCTA h215–18-months=0.13, meta-GCTA h224–30-months=0.14) and in concordance with additional twin analysis (5,733 pairs of European descent, h224-months=0.20).
| Item Type: | Journal Article | ||||||||
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| Subjects: | P Language and Literature > P Philology. Linguistics | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | ||||||||
| Library of Congress Subject Headings (LCSH): | Language acquisition -- Genetic aspects | ||||||||
| Journal or Publication Title: | Nature Communications | ||||||||
| Publisher: | Nature Publishing Group | ||||||||
| ISSN: | 2041-1723 | ||||||||
| Official Date: | 16 September 2014 | ||||||||
| Dates: |
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| Volume: | Volume 5 | ||||||||
| Page Range: | p. 4831 | ||||||||
| DOI: | 10.1038/ncomms5831 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 28 December 2015 | ||||||||
| Date of first compliant Open Access: | 28 December 2015 |
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