The Library
Scientific hypotheses can be tested by comparing the effects of one treatment over many diseases in a systematic review
Tools
Tools
Tools
Chen, Y-F., Hemming, Karla, Chilton, Peter J., Gupta, Keshav K., Altman, Douglas G. and Lilford, Richard (2014) Scientific hypotheses can be tested by comparing the effects of one treatment over many diseases in a systematic review. Journal of Clinical Epidemiology, Volume 67 (Number 12). pp. 1309-1319. doi:10.1016/j.jclinepi.2014.08.007
|
PDF
WRAP_Lilford_PIIS0895435614003394.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution. Download (1149Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.jclinepi.2014.08.007
Abstract
Objectives:
To describe the use of systematic reviews or overviews (systematic reviews of systematic reviews) to synthesize quantitative evidence of intervention effects across multiple indications (multiple-indication reviews) and to highlight issues pertaining to such reviews.
Study Design and Setting:
MEDLINE was searched from 2003 to January 2014. We selected multiple-indication reviews of interventions of allopathic medicine that included evidence from randomized controlled trials. We categorized the subject areas evaluated by these reviews and examined their methodology. Utilities and caveats of multiple-indication reviews are illustrated with examples drawn from published literature.
Results:
We retrieved 52 multiple-indication reviews covering a wide range of interventions. The method has been used to detect unintended effects, improve precision by pooling results across indications, and examine scientific hypotheses across disease classes.
Conclusion:
Systematic reviews of interventions are typically used to evaluate the effects of treatments, one indication at a time. Here, we argue that, with due attention to methodological caveats, much can be learned by comparing the effects of a given treatment across many related indications.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Medicine > Warwick Medical School |
||||||||
| Library of Congress Subject Headings (LCSH): | Clinical medicine | ||||||||
| Journal or Publication Title: | Journal of Clinical Epidemiology | ||||||||
| Publisher: | Elsevier Inc. | ||||||||
| ISSN: | 0895-4356 | ||||||||
| Official Date: | December 2014 | ||||||||
| Dates: |
|
||||||||
| Date of first compliant deposit: | 28 December 2015 | ||||||||
| Volume: | Volume 67 | ||||||||
| Number: | Number 12 | ||||||||
| Number of Pages: | 11 | ||||||||
| Page Range: | pp. 1309-1319 | ||||||||
| DOI: | 10.1016/j.jclinepi.2014.08.007 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | National Institute for Health Research (Great Britain) (NIHR), Collaborations for Leadership in Applied Health Research and Care (CLAHRC), Engineering and Physical Sciences Research Council (EPSRC), Medical Research Council (Great Britain) (MRC), Cancer Research UK (CRUK), National Institute for Health and Care Excellence (Great Britain) | ||||||||
| Grant number: | GR/S29874/01 (EPSRC) |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
